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Journal of Clinical Microbiology, February 2006, p. 662-665, Vol. 44, No. 2
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.2.662-665.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Group O Human Immunodeficiency Virus Type 1 Infection That Escaped Detection in Two Immmunoassays

Said Zouhair,1,3 Sylvie Roussin-Bretagne,2 Alain Moreau,4 Sylvie Brunet,4 Syria Laperche,5 Michèle Maniez,6 Francis Barin,4 and Martine Harzic1*

Laboratoire de Virologie, Département de Biologie Médicale,1 Service Hépato-Gastroentérologie, Centre Hospitalier de Versailles, Le Chesnay, France,2 Service de Microbiologie, Hôpital Militaire d'Instruction Mohamed V, Rabat, Morocco,3 Université François-Rabelais, Centre National de Référence du VIH, Tours, France,4 Centre National de Transfusion Sanguine, Paris, France,5 ETS de Lille, Lille, France6

Received 5 July 2005/ Returned for modification 22 August 2005/ Accepted 18 November 2005

We report a case of human immunodeficiency virus type 1 group O infection not detected by two highly sensitive immunoassays. The sera were strongly reactive to the V3 peptide of group O but not to the gp41 immunodominant epitope. Gp41 was sequenced, confirming that this virus belonged to group O.

* Corresponding author. Mailing address: Department of Biology, Hopital de Versailles, 177 Rue de Versailles, Le Chesnay 78150, France. Phone: 0033 139638751. Fax: 0033 139639312. E-mail: mharzic{at}ch-versailles.fr.

Journal of Clinical Microbiology, February 2006, p. 662-665, Vol. 44, No. 2
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.2.662-665.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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