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Journal of Clinical Microbiology, March 2006, p. 1081-1083, Vol. 44, No. 3
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.3.1081-1083.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Insertion Sequence IS900 Revisited

McGill University Health Center, Montreal, Quebec, Canada

Received 22 November 2005/ Returned for modification 28 December 2005/ Accepted 1 January 2006

Many studies investigating Mycobacterium avium subsp. paratuberculosis in Crohn's disease have used molecular detection of IS900 in clinical samples, but some have described polymorphisms in IS900 as variants of this organism. Analysis of 23 M. avium subsp. paratuberculosis isolates revealed that IS900 is highly conserved, with only two sequevars distinguishing sheep and cattle lineages. Amplification of IS900-like sequences is not sufficient as a proxy for M. avium subsp. paratuberculosis.

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