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Journal of Clinical Microbiology, March 2006, p. 1108-1110, Vol. 44, No. 3
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.3.1108-1110.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Application of UL144 Molecular Typing To Determine Epidemiology of Cytomegalovirus Infections in Preterm Infants

R. Stranska,1* R. Schuurman,1 M. Toet,2 M. Verboon-Maciolek,2 L. S. de Vries,2 and A. M. van Loon1

Department of Virology, Eijkman-Winkler Centre, University Medical Centre, Utrecht, The Netherlands,1 Department of Neonatology, Wilhelmina Children's Hospital, University Medical Centre, Utrecht, The Netherlands2

Received 22 April 2005/ Returned for modification 22 July 2005/ Accepted 24 October 2005

Sequence analysis of the UL144 gene of human cytomegalovirus (CMV) was used to investigate the epidemiology of CMV infections in preterm infants. Nosocomial transmission of CMV from congenitally infected infant to preterm twins was excluded based on distinct molecular profiles of CMV strains. Indistinguishable molecular profiles between strains from the mother and the infant indicated postnatal acquisition of CMV through breastfeeding.

* Corresponding author. Present address: Program in Molecular Medicine, University of Massachusetts, Worcester, MA 01604. Phone: 508 656 4583. Fax: 508 656 4583. E-mail: ruzena.stranska{at}umassmed.edu.

Journal of Clinical Microbiology, March 2006, p. 1108-1110, Vol. 44, No. 3
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.3.1108-1110.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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Copyright © 2006 by the American Society for Microbiology. All rights reserved.