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Journal of Clinical Microbiology, March 2006, p. 1111-1114, Vol. 44, No. 3
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.3.1111-1114.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Candida krusei Transmission among Hematology Patients Resolved by Adapted Antifungal Prophylaxis and Infection Control Measures

Margreet C. Vos,1* Hubert P. Endtz,1 Deborah Horst-Kreft,1 Jeanette Doorduijn,2 Elly Lugtenburg,2 Henri A. Verbrugh,1 Bob Löwenberg,2 Siem de Marie,1,3 Cindy van Pelt,1 and Alex van Belkum1

Department of Medical Microbiology & Infectious Diseases,1 Department of Hematology,2 Department of Internal Medicine, Section of Infectious Diseases, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands3

Received 14 July 2005/ Returned for modification 15 September 2005/ Accepted 15 December 2005

A sudden increase in neutropenic hematology patients with Candida krusei colonization and bacteremia prompted a longitudinal epidemiological investigation. We identified 39 patients; 13 developed candidemia, and three died; 25 patients carried the same genotype. We intervened by changing antifungal prophylaxis and implementing strict infection control measures. The incidence dropped immediately.

* Corresponding author. Mailing address: Department of Medical Microbiology & Infectious Diseases, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. Phone: 0031-10-4633510. Fax: 0031-10-4633875. E-mail: m.vos{at}erasmusmc.nl.

Journal of Clinical Microbiology, March 2006, p. 1111-1114, Vol. 44, No. 3
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.3.1111-1114.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Pfaller, M. A., Diekema, D. J., Gibbs, D. L., Newell, V. A., Nagy, E., Dobiasova, S., Rinaldi, M., Barton, R., Veselov, A., the Global Antifungal Surveillance Group, (2008). Candida krusei, a Multidrug-Resistant Opportunistic Fungal Pathogen: Geographic and Temporal Trends from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005. J. Clin. Microbiol. 46: 515-521 [Abstract] [Full Text]  


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