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Journal of Clinical Microbiology, March 2006, p. 1135-1138, Vol. 44, No. 3
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.3.1135-1138.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Distribution of the Serine-Aspartate Repeat Protein-Encoding sdr Genes among Nasal-Carriage and Invasive Staphylococcus aureus Strains

Artur Sabat,1 Damian C. Melles,2 Gayane Martirosian,3 Hajo Grundmann,4 Alex van Belkum,2 and Waleria Hryniewicz1*

National Institute of Public Health, 00-725 Warsaw, Poland,1 Erasmus MC University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands,2 Department of Medical Microbiology, Medical University of Silesia, Katowice, Poland,3 European Antimicrobial Resistance Surveillance System, RijksInstituut voor Volksgezondheid and Milieu (RIVM), Bilthoven, The Netherlands4

Received 28 September 2005/ Returned for modification 29 November 2005/ Accepted 6 January 2006

The sdr locus was found in all 497 investigated Staphylococcus aureus strains, although in 29 strains it contained only the sdrC gene (sdrD negative, sdrE negative). The sdrC-positive, sdrD-negative, sdrE-negative gene profile was exclusive to methicillin-sensitive S. aureus (MSSA) strains (Fisher's exact test; P = 0.0005) and was not found in the strains collected from bone infections (P = 0.0019). We also found a strong association between the presence of the sdrD gene and methicillin-resistant S. aureus strains (P < 0.0001). Our findings suggest that MSSA strains with the newly uncovered sdrC-positive, sdrD-negative, sdrE-negative gene profile have a substantially decreased potential to establish bone infection.

* Corresponding author. Mailing address: National Institute of Public Health, 30/34 Chelmska St., 00-725 Warsaw, Poland. Phone: 48 22 841 33 67. Fax: 48 22 841 29 49. E-mail: waleria{at}cls.edu.pl.

Journal of Clinical Microbiology, March 2006, p. 1135-1138, Vol. 44, No. 3
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.3.1135-1138.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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