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Journal of Clinical Microbiology, March 2006, p. 1135-1138, Vol. 44, No. 3
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.3.1135-1138.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Distribution of the Serine-Aspartate Repeat Protein-Encoding sdr Genes among Nasal-Carriage and Invasive Staphylococcus aureus Strains

National Institute of Public Health, 00-725 Warsaw, Poland,¹ Erasmus MC University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands,² Department of Medical Microbiology, Medical University of Silesia, Katowice, Poland,³ European Antimicrobial Resistance Surveillance System, RijksInstituut voor Volksgezondheid and Milieu (RIVM), Bilthoven, The Netherlands⁴

Received 28 September 2005/ Returned for modification 29 November 2005/ Accepted 6 January 2006

The sdr locus was found in all 497 investigated Staphylococcus aureus strains, although in 29 strains it contained only the sdrC gene (sdrD negative, sdrE negative). The sdrC-positive, sdrD-negative, sdrE-negative gene profile was exclusive to methicillin-sensitive S. aureus (MSSA) strains (Fisher's exact test; P = 0.0005) and was not found in the strains collected from bone infections (P = 0.0019). We also found a strong association between the presence of the sdrD gene and methicillin-resistant S. aureus strains (P < 0.0001). Our findings suggest that MSSA strains with the newly uncovered sdrC-positive, sdrD-negative, sdrE-negative gene profile have a substantially decreased potential to establish bone infection.

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