JCM Figure table search 04
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leyten, E. M. S.
Right arrow Articles by Arend, S. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leyten, E. M. S.
Right arrow Articles by Arend, S. M.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, March 2006, p. 1197-1201, Vol. 44, No. 3
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.3.1197-1201.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Use of Enzyme-Linked Immunospot Assay with Mycobacterium tuberculosis- Specific Peptides for Diagnosis of Recent Infection with M. tuberculosis after Accidental Laboratory Exposure

Eliane M. S. Leyten,1* Bert Mulder,3 Corine Prins,1 Karin Weldingh,4 Peter Andersen,4 Tom H. M. Ottenhoff,2 Jaap T. van Dissel,1 and Sandra M. Arend1*

Department of Infectious Diseases,1 Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands,2 Laboratory of Medical Microbiology Twente Achterhoek, Enschede, The Netherlands,3 Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark4

Received 1 December 2005/ Accepted 27 December 2005

This report of an accidental exposure to Mycobacterium tuberculosis in a microbiological laboratory illustrates the value of gamma interferon enzyme-linked immunospot assay using peptides of ESAT-6, CFP-10, TB37.6, and TB7.7 for the diagnosis of latent infection. In particular, positive responses to peptides 2 to 6 of TB37.6 were observed exclusively in recently infected persons.

* Corresponding author. Mailing address: Dept. of Infectious Diseases, C5P, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. Phone: 31 71 526 26 13. Fax: 31 71 526 67 58. E-mail for Sandra M. Arend: S.M.Arend{at}LUMC.nl. E-mail for Elaine M. S. Leyten: e.m.s.leyten{at}LUMC.nl.

Journal of Clinical Microbiology, March 2006, p. 1197-1201, Vol. 44, No. 3
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.3.1197-1201.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 2006 by the American Society for Microbiology. All rights reserved.