This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Clarke, S. C.
Right arrow Articles by Edwards, G. F. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Clarke, S. C.
Right arrow Articles by Edwards, G. F. S.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, April 2006, p. 1224-1228, Vol. 44, No. 4
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.4.1224-1228.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Potential Impact of Conjugate Vaccine on the Incidence of Invasive Pneumococcal Disease among Children in Scotland

Stuart C. Clarke,1,2,3* Johanna M. Jefferies,1 Andrew J. Smith,4 Jim McMenamin,5 Timothy J. Mitchell,2 and Giles F. S. Edwards1

Scottish Meningococcus and Pneumococcus Reference Laboratory, Glasgow, United Kingdom,1 Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, United Kingdom,2 Portsmouth City PCT, Portsmouth, United Kingdom,3 Glasgow Dental School, Glasgow, United Kingdom,4 Health Protection Scotland, Glasgow, United Kingdom5

Received 21 October 2005/ Returned for modification 18 November 2005/ Accepted 3 February 2006

We sought to determine the potential impact of seven-valent pneumococcal conjugate vaccine on the incidence of invasive pneumococcal disease (IPD) among children in Scotland. Invasive pneumococci from blood and cerebrospinal fluid, isolated between 2000 and 2004 from all children aged less than 5 years in Scotland, were characterized by serotyping. Using reported efficacy data of the seven-valent pneumococcal conjugate vaccine (PCV7) along with likely coverage rates, we made an estimation of the potential impact on the incidence of IPD among children in Scotland. A total of 217 pneumococci were characterized into 22 different serogroups/types, the most common, in rank order, being 14, 19F, 6B, 18C, 23F, 9V, 4, 1, 19A, and 6A. Estimated serotype coverage for PCV7 was 76.5% in those aged less than 5 years of age but increased to 88.9% for those aged 1 year. By using serotype coverage and estimates of vaccine efficacy and uptake, the potential impact of the vaccine for those greater than 2 months of age, but less than 5 years, was estimated as 67.3%, leading to an average of 29 preventable cases per year. The introduction of PCV7 into the childhood immunization schedule would reduce the burden of pneumococcal disease in children, and the incidence would be particularly reduced in those children aged 1 year. Additional benefits may be gained in adults through herd protection. Continued surveillance of IPD is required before, during, and after the introduction of PCV7.

* Corresponding author. Mailing address: Department of Public Health, Portsmouth City PCT, Finchdean House, Milton Road, Portsmouth PO3 6DP, United Kingdom. Phone: 44 2392 835318. Fax: 44 2392 955312. E-mail: stuartcclarke{at}hotmail.com.

Journal of Clinical Microbiology, April 2006, p. 1224-1228, Vol. 44, No. 4
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.4.1224-1228.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Farrell, D. J., Felmingham, D., Shackcloth, J., Williams, L., Maher, K., Hope, R., Livermore, D. M., George, R. C., Brick, G., Martin, S., Reynolds, R., on behalf of the BSAC Working Parties on Resistanc, (2008). Non-susceptibility trends and serotype distributions among Streptococcus pneumoniae from community-acquired respiratory tract infections and from bacteraemias in the UK and Ireland, 1999 to 2007. J Antimicrob Chemother 62: ii87-ii95 [Abstract] [Full Text]  
  • Clarke, S. C. (2006). Control of pneumococcal disease in the United Kingdom - the start of a new era.. J Med Microbiol 55: 975-980 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»