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Journal of Clinical Microbiology, April 2006, p. 1257-1261, Vol. 44, No. 4
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.4.1257-1261.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Phylogenetic Lineages of Invasive and Colonizing Strains of Serotype III Group B Streptococci from Neonates: a Multicenter Prospective Study

Feng-Ying C. Lin,^1* April Whiting,² Elisabeth Adderson,³ Shinji Takahashi,⁴ Diane Marie Dunn,⁵ Robert Weiss,⁵ Parvin H. Azimi,⁶ Joseph B. Philips III,^1,7 Leonard E. Weisman,⁸ Joan Regan,^9, Penny Clark,¹⁰ George G. Rhoads,¹¹ Carl E. Frasch,¹² James Troendle,¹ Patricia Moyer,¹ and John F. Bohnsack²

National Institute of Child Health and Human Development, National Institutes of Health,¹ Center for Biologics Research and Review, Food and Drug Administration, Department of Health and Human Services, Bethesda, Maryland,¹² Department of Pediatrics,² Genome Center, University of Utah Health Sciences Center, Salt Lake City, Utah,⁵ Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee,³ Division of Microbiology, Joshi-Eiyoh University, Saitama, Japan,⁴ Children's Hospital Medical Center of Northern California, Oakland, California,⁶ University of Alabama at Birmingham, Birmingham, Alabama,⁷ Baylor College of Medicine, Houston, Texas,⁸ Columbia University Health Sciences, New York, New York,⁹ University of Florida, Gainesville, Florida,¹⁰ University of Dentistry and Medicine of New Jersey, Piscataway, New Jersey,¹¹

Received 3 November 2005/ Returned for modification 17 December 2005/ Accepted 22 January 2006

This study compares the phylogenetic lineages of invasive serotype III group B streptococci (GBS) to those of colonizing strains in order to determine lineages associated with invasive disease. Isolates from 29 infants with early-onset disease (EOD) and from 196 colonized infants, collected in a prospective, multicenter study, were assigned a sequence type (ST) by multilocus sequence typing. Overall, 54.5% of the isolates were in the ST-19 complex, and 40.4% were in the ST-17 complex. Invasive strains were more likely to be in the ST-17 complex than were colonizing strains (59% versus 38%, P = 0.03). After we adjusted for potential confounders, the ST-17 complex was more likely to be associated with EOD than were other lineages (odds ratio = 2.51, 95% confidence interval = 1.02 to 6.20). These data support the hypothesis that ST-17 complex GBS are more virulent than other serotype III GBS.

Deceased.

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