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Journal of Clinical Microbiology, April 2006, p. 1400-1404, Vol. 44, No. 4
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.4.1400-1404.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Dynamics of Appearance and Expansion of a Prolyliminopeptidase- Negative Subtype among Neisseria gonorrhoeae Isolates Collected in Sydney, Australia, from 2002 to 2005

E. Athena Limnios, Nhu-Lan Nguyen, Sanghamitra Ray, Christopher J. McIver, and John W. Tapsall*

Department of Microbiology, The Prince of Wales Hospital, Randwick, Sydney, New South Wales, Australia

Received 4 November 2005/ Returned for modification 17 December 2005/ Accepted 28 January 2006

Recent studies have demonstrated a wide geographic circulation of isolates of Neisseria gonorrhoeae that fail to produce prolyliminopeptidase (PIP). Tests based on the production of this enzyme are important elements of a number of identification systems for gonococci. We documented the appearance, expansion, and contraction of subtypes of 165 PIP-negative gonococci detected in an extended and systematic sample of the 3,926 N. gonorrhoeae isolates collected in Sydney, Australia, from July 2002 to September 2005. Their appearance, peak, and decline followed an "epidemic" curve. At the peak of their prevalence in 2003, PIP-negative gonococci comprised 22% of all isolates. Closely related phenotypes accounted for 162/165 of the PIP-negative gonococci. Algorithms for confirmation of N. gonorrhoeae should take account of the temporal and geographic variability of gonococci by utilizing two or more distinct confirmatory methods.

* Corresponding author. Mailing address: Department of Microbiology, The Prince of Wales Hospital, Barker Street, Randwick, New South Wales, Australia 2031. Phone: 612 9382 9079. Fax: 612 9398 4275. E-mail: john.tapsall{at}sesiahs.health.nsw.gov.au.

Journal of Clinical Microbiology, April 2006, p. 1400-1404, Vol. 44, No. 4
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.4.1400-1404.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Unemo, M., Fasth, O., Fredlund, H., Limnios, A., Tapsall, J. (2009). Phenotypic and genetic characterization of the 2008 WHO Neisseria gonorrhoeae reference strain panel intended for global quality assurance and quality control of gonococcal antimicrobial resistance surveillance for public health purposes. J Antimicrob Chemother 63: 1142-1151 [Abstract] [Full Text]  
  • Tapsall, J. W., Limnios, E. A., Murphy, D., on behalf of the Australian Gonococcal Surveillanc, (2008). Analysis of trends in antimicrobial resistance in Neisseria gonorrhoeae isolated in Australia, 1997 2006. J Antimicrob Chemother 61: 150-155 [Abstract] [Full Text]  
  • Whiley, D. M., Limnios, E. A., Ray, S., Sloots, T. P., Tapsall, J. W. (2007). Diversity of penA Alterations and Subtypes in Neisseria gonorrhoeae Strains from Sydney, Australia, That Are Less Susceptible to Ceftriaxone. Antimicrob. Agents Chemother. 51: 3111-3116 [Abstract] [Full Text]  
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