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Journal of Clinical Microbiology, April 2006, p. 1558-1560, Vol. 44, No. 4
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.4.1558-1560.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Microevolution of the Direct Repeat Locus of Mycobacterium tuberculosis in a Strain Prevalent in San Francisco

Roxanne S. Aga,1,{dagger} Elizabeth Fair,1,{ddagger} Neil F. Abernethy,1,{ddagger} Kathryn DeRiemer,1,{dagger} E. Antonio Paz,2 L. Masae Kawamura,2 Peter M. Small,1,§ and Midori Kato-Maeda1*

Division of Infectious Diseases and Geographic Medicine, Stanford University Medical Center, 300 Pasteur Drive, Grant Building, Room S-169, Stanford, California 94305-5107,1 San Francisco TB Control Section, Department of Public Health Ward 94, 1001 Potrero Avenue, San Francisco, California 941102

Received 10 February 2006/ Accepted 16 February 2006

We describe a microevolutionary event of a prevalent strain of Mycobacterium tuberculosis that caused two outbreaks in San Francisco. During the second outbreak, a direct variable repeat was lost. We discuss the mechanisms of this change and the implications of analyzing multiple genetic loci in this context.

* Corresponding author. Present address: Division of Pulmonary and Critical Care Medicine, Department of Medicine-SFGH, UCSF, 1001 Potrero Avenue, San Francisco General Hospital, Mail Box 0841, San Francisco, CA 94110. Phone: (415) 206-8121. Fax: (415) 695-1551. E-mail: midori.kato-maeda{at}ucsf.edu.

{dagger} Present address: School of Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616.

{ddagger} Present address: Division of Pulmonary and Critical Care Medicine, Department of Medicine-SFGH, UCSF, 1001 Potrero Avenue, San Francisco General Hospital, Mail Box 0841, San Francisco, CA 94110.

§ Present address: Institute for Systems Biology, 1441 N 34th St., Seattle, WA 98103-8904.

Journal of Clinical Microbiology, April 2006, p. 1558-1560, Vol. 44, No. 4
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.4.1558-1560.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Streicher, E. M., Victor, T. C., van der Spuy, G., Sola, C., Rastogi, N., van Helden, P. D., Warren, R. M. (2007). Spoligotype Signatures in the Mycobacterium tuberculosis Complex. J. Clin. Microbiol. 45: 237-240 [Abstract] [Full Text]  


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