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Journal of Clinical Microbiology, April 2006, p. 1561-1563, Vol. 44, No. 4
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.4.1561-1563.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Early Detection of Hepatitis C Virus Infection by Use of a New Combined Antigen-Antibody Detection Assay: Potential Use for High-Risk Individuals

A. Schnuriger,1 S. Dominguez,2 M.-A. Valantin,2 R. Tubiana,2 C. Duvivier,2 J. Ghosn,2 A. Simon,3 C. Katlama,2 and V. Thibault1*

Virology,1 Infectious Diseases,2 Internal Medicine Departments, Pitié-Salpêtrière Hospital, Paris, France3

Received 8 September 2005/ Returned for modification 29 October 2005/ Accepted 26 January 2006

The performance of a new combined antigen-antibody assay (Monolisa HCV Ag-Ab Ultra; Bio-Rad Laboratories) was evaluated in the context of acute hepatitis C in human immunodeficiency virus-infected patients. The combined assay became positive as early as the first PCR and earlier than a third-generation enzyme-linked immunosorbent assay in 65% of the cases. Reduction of the long period of HCV seronegativity should improve the diagnosis of hepatitis C infection, especially in high-risk populations.

* Corresponding author. Mailing address: Department of Virology, Hôpital La Pitié-Salpêtrière, 83, Boulevard de l'Hôpital, 75651 Paris Cedex 13, France. Phone: 00 33 (0)1 42 17 74 26. Fax: 00 33 (0)1 42 17 74 11. E-mail: vincent.thibault{at}psl.aphp.fr.

Journal of Clinical Microbiology, April 2006, p. 1561-1563, Vol. 44, No. 4
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.4.1561-1563.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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Copyright © 2006 by the American Society for Microbiology. All rights reserved.