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Journal of Clinical Microbiology, April 2006, p. 1564-1566, Vol. 44, No. 4
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.4.1564-1566.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Discovery of the Neutralizing Epitope Common to Influenza B Virus Victoria Group Isolates in Japan

Department of Microbiology, Kobe Institute of Health, 4-6, Minatojima-nakamachi, Chuo-ku, Kobe 650-0046, Japan,¹ Diagnostics Research Laboratories, Wako Pure Chemical Industries, Ltd., 6-1, Takada-cho, Amagasaki 661-0963, Japan,² Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69, 1-Chome, Nakamichi, Higashinari-ku, Osaka 537-0025, Japan³

Received 2 December 2005/ Returned for modification 24 January 2006/ Accepted 13 February 2006

Monoclonal antibody 9B2 possesses hemagglutination inhibition activity against all the 2002/2003 influenza B virus Victoria group isolates in Kobe, Japan, as well as representative strains isolated between 1987 and 1997. The 9B2 epitope localizes three-dimensionally in the vicinity of antigenic site A of the hemagglutinin molecule, and amino acid substitutions in this region affected the binding of 9B2.

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