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Journal of Clinical Microbiology, April 2006, p. 1581-1583, Vol. 44, No. 4
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.4.1581-1583.2006

Evaluation of Diagnostic Assays for Hepatitis E Virus in Outbreak Settings

Khin Saw Aye Myint,1* Timothy P. Endy,2 Robert V. Gibbons,1 Kanti Laras,3 Mammen P. Mammen Jr.,1 Endang R. Sedyaningsih,4 Jitvimol Seriwatana,2 Jonathan S. Glass,3 Sumitda Narupiti,1 and Andrew L. Corwin3

Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand,1 Walter Reed Army Institute of Research, Silver Spring, Maryland,2 U.S. Naval Medical Research Unit No. 2,3 National Institute of Health Research and Development, Indonesian Ministry of Health, Jakarta, Indonesia4

Received 1 December 2005/ Returned for modification 16 January 2006/ Accepted 6 February 2006

Hepatitis E virus (HEV) is a major cause of hepatitis. We evaluated five HEV antibody diagnostic assays by using outbreak specimens. The Abbott immunoglobulin G (IgG), Genelabs IgG, and Walter Reed Army Institute of Research (WRAIR) IgM assays were about 90% sensitive; the Abbott IgG and WRAIR total Ig and IgM assays were more than 90% specific.

* Corresponding author. Mailing address: Department of Virology, USAMC-AFRIMS, 315/6 Rajvithi Road, Bangkok 1040, Thailand. Phone: 66-2-6444674. Fax: 66-2-6444760. E-mail:myintk{at}afrims.org.

Journal of Clinical Microbiology, April 2006, p. 1581-1583, Vol. 44, No. 4
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.4.1581-1583.2006




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