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Journal of Clinical Microbiology, April 2006, p. 1584-1586, Vol. 44, No. 4
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.4.1584-1586.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Fulminant, Acyclovir-Resistant, Herpes Simplex Virus Type 2 Hepatitis in an Immunocompetent Woman

Todd Czartoski,1,2,8* Charlie Liu,3 David M. Koelle,1,3,4,8 Stephen Schmechel,5 Andrea Kalus,6 and Anna Wald1,3,7,8

Departments of Medicine,1 Neurology,2 Laboratory Medicine,3 Pathobiology,4 Pathology,5 Dermatology,6 Epidemiology, University of Washington, Seattle, Washington 98195,7 Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington 981098

Received 30 September 2005/ Returned for modification 10 December 2005/ Accepted 31 January 2006

We report an immunocompetent woman with multisystem organ failure following herpes simplex virus type 2 (HSV-2) hepatitis. After she initially responded to intravenous acyclovir, she was switched to oral valacyclovir. She developed respiratory failure and opportunistic infections and died. Autopsy confirmed disseminated HSV infection, and lung tissue grew acyclovir-resistant HSV-2.

* Corresponding author. Mailing address: Molecular Virology Laboratory, University of Washington, 960 Republican St., Seattle, WA 98195. Phone: (206) 732-6114. Fax: (206) 732-6109. E-mail: tczar{at}u.washington.edu.

Journal of Clinical Microbiology, April 2006, p. 1584-1586, Vol. 44, No. 4
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.4.1584-1586.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Wang, K., Mahalingam, G., Hoover, S. E., Mont, E. K., Holland, S. M., Cohen, J. I., Straus, S. E. (2007). Diverse Herpes Simplex Virus Type 1 Thymidine Kinase Mutants in Individual Human Neurons and Ganglia. J. Virol. 81: 6817-6826 [Abstract] [Full Text]  


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