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Journal of Clinical Microbiology, May 2006, p. 1831-1833, Vol. 44, No. 5
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.5.1831-1833.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Sensitivity of the Multispot HIV-1/HIV-2 Rapid Test Using Samples from Human Immunodeficiency Virus Type 1-Positive Individuals with Various Levels of Exposure to Highly Active Antiretroviral Therapy

Robert J. O'Connell,1,4* Brian K. Agan,1,3,4 Stephanie A. Anderson,1,3 Jennifer A. Malia,2 and Nelson L. Michael2,4

Wilford Hall USAF Medical Center, Lackland AFB, Texas 78236,1 Walter Reed Army Institute of Research, Rockville, Maryland 20850,2 Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland 20852,3 Triservice AIDS Clinical Consortium, Rockville, Maryland 208524

Received 20 October 2005/ Returned for modification 16 February 2006/ Accepted 21 February 2006

The Multispot HIV-1/HIV-2 rapid test detects human immunodeficiency virus type 1 (HIV-1) gp41 antibodies, which can wane over time in some HIV-1-infected populations, resulting in false-negative screening results. Multispot sensitivity was 100% using 248 sera from one such population, and it correctly identified serostatus in individuals who previously tested false negative with rapid testing.

* Corresponding author. Mailing address: Wilford Hall USAF Medical Center, Lackland AFB, TX 78236. Phone: (210) 292-2225. Fax: (210) 292-3740. E-mail: robert.oconnell{at}lackland.af.mil.

Journal of Clinical Microbiology, May 2006, p. 1831-1833, Vol. 44, No. 5
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.5.1831-1833.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
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Copyright © 2006 by the American Society for Microbiology. All rights reserved.