This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Friedrich, A. W.
Right arrow Articles by Karch, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Friedrich, A. W.
Right arrow Articles by Karch, H.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, May 2006, p. 1844-1846, Vol. 44, No. 5
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.5.1844-1846.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Cytolethal Distending Toxin in Escherichia coli O157:H7: Spectrum of Conservation, Structure, and Endothelial Toxicity

Alexander W. Friedrich,1 Shan Lu,1,2 Martina Bielaszewska,1 Rita Prager,3 Phillip Bruns,4 Jian-Guo Xu,2 Helmut Tschäpe,3 and Helge Karch1*

Institute for Hygiene, the National Consulting Laboratory on Hemolytic Uremic Syndrome, University Hospital Münster, Robert Koch Str. 41, and the IZKF Münster, 48149 Münster, Germany,1 State Key Laboratory of Infectious Diseases Prevention and Control (China CDC), National Institute for Communicable Disease Prevention and Control, China CDC, Beijing, People's Republic of China,2 National Reference Centre for Salmonella and Other Enteric Pathogens, Robert Koch Institute, Branch Wernigerode, Burgstr. 37, 38855 Wernigerode, Germany,3 Department for Periodontology, University Hospital Münster, Waldeyerstr. 30, 48149 Münster, Germany4

Received 13 December 2005/ Returned for modification 8 February 2006/ Accepted 6 March 2006

We identified the cytolethal distending toxin V (CDT-V) gene cluster in 19 (4.9%) of 391 enterohemorrhagic Escherichia coli O157:H7. cdt-V+ strains belonged to five phage types (PTs) and were most frequent within PTs 14 and 34. CDT-V was expressed in all but two cdt-V+ strains and was lethal to cultured endothelial cells. Subtyping schemes should include cdt-V as a marker to differentiate E. coli O157:H7 even within the same phage type.

* Corresponding author. Mailing address: Institut für Hygiene, Universitätsklinikum Münster, Robert-Koch-Str., 41, 48149 Münster, Germany. Phone: 49-251/8355361. Fax: 49-251/8355341. E-mail: hkarch{at}uni-muenster.de.

Journal of Clinical Microbiology, May 2006, p. 1844-1846, Vol. 44, No. 5
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.5.1844-1846.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Slanec, T., Fruth, A., Creuzburg, K., Schmidt, H. (2009). Molecular Analysis of Virulence Profiles and Shiga Toxin Genes in Food-Borne Shiga Toxin-Producing Escherichia coli. Appl. Environ. Microbiol. 75: 6187-6197 [Abstract] [Full Text]  
  • Toth, I., Schmidt, H., Kardos, G., Lancz, Z., Creuzburg, K., Damjanova, I., Paszti, J., Beutin, L., Nagy, B. (2009). Virulence Genes and Molecular Typing of Different Groups of Escherichia coli O157 Strains in Cattle. Appl. Environ. Microbiol. 75: 6282-6291 [Abstract] [Full Text]  
  • Bielaszewska, M., Stoewe, F., Fruth, A., Zhang, W., Prager, R., Brockmeyer, J., Mellmann, A., Karch, H., Friedrich, A. W. (2009). Shiga Toxin, Cytolethal Distending Toxin, and Hemolysin Repertoires in Clinical Escherichia coli O91 Isolates. J. Clin. Microbiol. 47: 2061-2066 [Abstract] [Full Text]  
  • Musken, A., Bielaszewska, M., Greune, L., Schweppe, C. H., Muthing, J., Schmidt, H., Schmidt, M. A., Karch, H., Zhang, W. (2008). Anaerobic Conditions Promote Expression of Sfp Fimbriae and Adherence of Sorbitol-Fermenting Enterohemorrhagic Escherichia coli O157:NM to Human Intestinal Epithelial Cells. Appl. Environ. Microbiol. 74: 1087-1093 [Abstract] [Full Text]  
  • Asakura, M., Hinenoya, A., Alam, M. S., Shima, K., Zahid, S. H., Shi, L., Sugimoto, N., Ghosh, A. N., Ramamurthy, T., Faruque, S. M., Nair, G. B., Yamasaki, S. (2007). An inducible lambdoid prophage encoding cytolethal distending toxin (Cdt-I) and a type III effector protein in enteropathogenic Escherichia coli. Proc. Natl. Acad. Sci. USA 104: 14483-14488 [Abstract] [Full Text]  
  • Orth, D., Grif, K., Dierich, M. P., Wurzner, R. (2006). Cytolethal distending toxins in Shiga toxin-producing Escherichia coli: alleles, serotype distribution and biological effects.. J Med Microbiol 55: 1487-1492 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»