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Journal of Clinical Microbiology, May 2006, p. 1844-1846, Vol. 44, No. 5
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.5.1844-1846.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Cytolethal Distending Toxin in Escherichia coli O157:H7: Spectrum of Conservation, Structure, and Endothelial Toxicity

Institute for Hygiene, the National Consulting Laboratory on Hemolytic Uremic Syndrome, University Hospital Münster, Robert Koch Str. 41, and the IZKF Münster, 48149 Münster, Germany,¹ State Key Laboratory of Infectious Diseases Prevention and Control (China CDC), National Institute for Communicable Disease Prevention and Control, China CDC, Beijing, People's Republic of China,² National Reference Centre for Salmonella and Other Enteric Pathogens, Robert Koch Institute, Branch Wernigerode, Burgstr. 37, 38855 Wernigerode, Germany,³ Department for Periodontology, University Hospital Münster, Waldeyerstr. 30, 48149 Münster, Germany⁴

Received 13 December 2005/ Returned for modification 8 February 2006/ Accepted 6 March 2006

We identified the cytolethal distending toxin V (CDT-V) gene cluster in 19 (4.9%) of 391 enterohemorrhagic Escherichia coli O157:H7. cdt-V⁺ strains belonged to five phage types (PTs) and were most frequent within PTs 14 and 34. CDT-V was expressed in all but two cdt-V⁺ strains and was lethal to cultured endothelial cells. Subtyping schemes should include cdt-V as a marker to differentiate E. coli O157:H7 even within the same phage type.

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