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Journal of Clinical Microbiology, May 2006, p. 1847-1850, Vol. 44, No. 5
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.5.1847-1850.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Polymorphisms in the Genes Encoding Chemokine Receptor 5, Interleukin-10, and Monocyte Chemoattractant Protein 1 Contribute to Cytomegalovirus Reactivation and Disease after Allogeneic Stem Cell Transplantation

Juergen Loeffler,1* Michael Steffens,2 Eva-Maria Arlt,3 Mohammad-Reza Toliat,4 Markus Mezger,1 Anita Suk,4 Thomas F. Wienker,2 Holger Hebart,3 Peter Nürnberg,4 Michael Boeckh,5 Per Ljungman,6 Rudolf Trenschel,7 and Hermann Einsele1

Julius-Maximilians-Universität Würzburg, Medizinische Klinik II, 97070 Würzburg, Germany,1 Institut für Medizinische Biometrie, Informatik und Epidemiologie der Rheinischen Friedrich-Wilhelms-Universität, 53105 Bonn, Germany,2 Eberhard-Karls-Universität, Medizinische Klinik II, 72076 Tübingen, Germany,3 Cologne Center for Genomics, 50674 Cologne, Germany,4 Fred Hutchinson Cancer Research Center, Seattle, Washington 98109,5 Department of Hematology, Karolinska University Hospital/Huddinge Hospital, Stockholm, Sweden,6 Medizinische Universitätsklinik Essen, 45123 Essen, Germany7

Received 10 August 2005/ Returned for modification 12 December 2005/ Accepted 7 March 2006

We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis.

* Corresponding author. Mailing address: Medizinische Klinik II, Klinikstrasse 6-8, 97070 Würzburg, Germany. Phone: 49 931 329 3618. Fax: 49 931 329 3630. E-mail: loeffler_j{at}klinik.uni-wuerzburg.de.

Journal of Clinical Microbiology, May 2006, p. 1847-1850, Vol. 44, No. 5
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.5.1847-1850.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Mezger, M., Steffens, M., Beyer, M., Manger, C., Eberle, J., Toliat, M.-R., Wienker, T. F., Ljungman, P., Hebart, H., Dornbusch, H. J., Einsele, H., Loeffler, J. (2008). Polymorphisms in the chemokine (C-X-C motif) ligand 10 are associated with invasive aspergillosis after allogeneic stem-cell transplantation and influence CXCL10 epression in monocyte-derived dendritic cells. Blood 111: 534-536 [Abstract] [Full Text]  


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