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Journal of Clinical Microbiology, May 2006, p. 1877-1880, Vol. 44, No. 5
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.5.1877-1880.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Plasma and Liver Hepatitis C Virus Variability in Patients Coinfected with Human Immunodeficiency Virus

Anne-Christine Jouvencel,1 Didier Neau,2 Muriel Faure,1 Martine Neau,3 Christophe Martinaud,1 Elisabeth Legrand,1 Pascale Trimoulet,1 Isabelle Garrigue,1 Brigitte Le Bail,4 Paulette Bioulac-Sage,4 Michel Dupon,2 Jean-Marie Ragnaud,2 Herve Fleury,1 and Marie-Edith Lafon1*

Laboratoire de Virologie EA2968, Universite Victor Segalen Bordeaux 2, 146 Rue Léo Saignat, 33076 Bordeaux, France,1 Federation des Maladies Infectieuses,2 Unité de Transplantation Hépatique,3 Service d'Anatomie-Pathologique, Hôpital Pellegrin, CHU de Bordeaux, Place Amélie Raba Léon, 33076 Bordeaux, France4

Received 9 September 2005/ Returned for modification 14 November 2005/ Accepted 22 February 2006

Liver and plasma hepatitis C virus (HCV) variability was compared by E2 cloning and sequencing in three patients coinfected with HCV and human immunodeficiency virus (HIV) before and after interferon treatment and in three patients solely infected with HCV. The plasma and liver samples contained unique sequences. In the patients coinfected with HIV, accumulated random mutations produced mostly nonsynonymous substitutions in contrast to the reduced HCV genetic variability seen after treatment.

* Corresponding author. Mailing address: Laboratoire de Virologie EA2968, Universite Victor Segalen Bordeaux 2, 146 Rue Léo Saignat, 33076 Bordeaux, France. Phone: (33) 5 57 57 13 63. Fax: (33) 5 56 99 11 40. E-mail: marie-edith.lafon{at}viro.u-bordeaux2.fr.

Journal of Clinical Microbiology, May 2006, p. 1877-1880, Vol. 44, No. 5
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.5.1877-1880.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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