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Detection of Carcinogenic Human Papillomavirus in Specimens Collected with a Novel Self-Sampling Device

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, and Departments of,¹ Family Medicine and Community Health,² Epidemiology and Public Health,³ Obstetrics and Gynecology, University of Miami School of Medicine, Miami, Florida⁴

Received 10 November 2005/ Returned for modification 9 January 2006/ Accepted 10 April 2006

We compared the detection of carcinogenic human papillomavirus DNA in cervicovaginal specimens self-collected using a novel device to the detection in physician-collected cervical specimens from 137 women. The kappa value was 0.66 (95% confidence interval, 0.53 to 0.78), with an 83% overall test agreement and a 68% positive test agreement.