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Journal of Clinical Microbiology, June 2006, p. 2237-2239, Vol. 44, No. 6
0095-1137/06/$08.00+0     doi:10.1128/JCM.00285-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Value of the Chlorhexidine Decontamination Method for Recovery of Nontuberculous Mycobacteria from Sputum Samples of Patients with Cystic Fibrosis

Agnès Ferroni,1* Hoang Vu-Thien,2 Philippe Lanotte,3 Muriel Le Bourgeois,4 Isabelle Sermet-Gaudelus,5 Brigitte Fauroux,6 Sophie Marchand,7 Françoise Varaigne,8 Patrick Berche,1 Jean-Louis Gaillard,9 and Catherine Offredo1

Laboratoire de Microbiologie, Hôpital Necker-Enfants Malades, Assistance Publique—Hôpitaux de Paris (AP-HP), Paris,1 Laboratoire de Microbiologie, Hôpital Trousseau, AP-HP, Paris,2 Laboratoire de Microbiologie, Hôpital Bretonneau, Tours,3 Service de Pneumologie-Allergologie Pédiatrique,4 Service de Pédiatrie Générale, Hôpital Necker-Enfants Malades, AP-HP, Paris,5 Service de Pneumologie Pédiatrique, Hôpital Trousseau, AP-HP, Paris,6 Service de Pédiatrie, Hôpital Pédiatrique Gatien de Clocheville, Tours,7 Service de Pneumologie, Hôpital Bretonneau, Tours,8 Laboratoire de Microbiologie, Hôpital Raymond Poincaré, AP-HP, Garches, France9

Received 9 February 2006/ Returned for modification 27 March 2006/ Accepted 5 April 2006

The chlorhexidine method was compared to the N-acetyl-L-cysteine-NaOH-oxalic acid decontamination method currently recommended for the recovery of nontuberculous mycobacteria (NTM) from patients with cystic fibrosis. Sputum samples (n = 827) treated with chlorhexidine yielded twice as many NTM-positive cultures as those treated by the reference method (54 [6.50%] versus 27 [3.25%]; P < 0.0001) despite a higher contamination rate (20% versus 14.2%; P = 0.0017).

* Corresponding author. Mailing address: Service de Microbiologie, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75015 Paris, France. Phone: 33 1 44 49 49 62. Fax: 33 1 44 49 49 60. E-mail: agnes.ferroni{at}nck.aphp.fr.

Journal of Clinical Microbiology, June 2006, p. 2237-2239, Vol. 44, No. 6
0095-1137/06/$08.00+0     doi:10.1128/JCM.00285-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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