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Journal of Clinical Microbiology, June 2006, p. 2271-2275, Vol. 44, No. 6
0095-1137/06/$08.00+0     doi:10.1128/JCM.01890-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Novel Recombinant Norovirus Causing Outbreaks of Gastroenteritis in Santiago, Chile

Roberto Vidal,1 Patricia Roessler,1 Verónica Solari,2 Jimena Vollaire,2 Xi Jiang,3 David O. Matson,4 Nora Mamani,1 Valeria Prado,1 and Miguel L. O'Ryan1*

Programa de Microbiología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, Chile,1 Servicio de Salud Metropolitano del Ambiente (SESMA), Ministerio de Salud de Chile, Santiago, Chile,2 Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio,3 Center for Pediatric Research, Eastern Virginia Medical School and Children's Hospital of The King's Daughters, Norfolk, Virginia4

Received 9 September 2005/ Returned for modification 18 October 2005/ Accepted 8 February 2006

Capsid and polymerase (RdRp) genes of 13 norovirus outbreak strains from Chile were compared. The genes sequences were discordant for five strains, and recombination was confirmed for two of them by amplification of a 1,360-bp gene segment containing a fragment of both genes. These strains belonged to a novel genogroup by RdRp sequence and to genogroup GII/3 by capsid sequence. Determining the clinical and epidemiological impact of human calicivirus recombination will require future studies.


* Corresponding author. Mailing address: Microbiology Program, ICBM, Faculty of Medicine, University of Chile, Independencia 1027, Santiago, Chile. Phone: 562 6786642. Fax: 562 7355855. E-mail: moryan{at}med.uchile.cl.


Journal of Clinical Microbiology, June 2006, p. 2271-2275, Vol. 44, No. 6
0095-1137/06/$08.00+0     doi:10.1128/JCM.01890-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.




This article has been cited by other articles:

  • Bull, R. A., Tanaka, M. M., White, P. A. (2007). Norovirus recombination. J. Gen. Virol. 88: 3347-3359 [Abstract] [Full Text]  
  • Coyne, K. P., Gaskell, R. M., Dawson, S., Porter, C. J., Radford, A. D. (2007). Evolutionary Mechanisms of Persistence and Diversification of a Calicivirus within Endemically Infected Natural Host Populations. J. Virol. 81: 1961-1971 [Abstract] [Full Text]