This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lindh, M. Articles by Norkrans, G. Search for Related Content PubMed PubMed Citation Articles by Lindh, M. Articles by Norkrans, G.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, July 2006, p. 2587-2589, Vol. 44, No. 7
0095-1137/06/$08.00+0     doi:10.1128/JCM.00265-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Lamivudine Resistance of Hepatitis B Virus Masked by Coemergence of Mutations in Probe Region of the COBAS AMPLICOR Assay

Departments of Clinical Virology,¹ Infectious Diseases, Göteborg University, Göteborg, Sweden²

Received 6 February 2006/ Returned for modification 20 March 2006/ Accepted 14 May 2006

The COBAS AMPLICOR hepatitis B virus assay targets a conserved region of the genome and is widely used to monitor treatment of hepatitis B in order to identify emerging resistance. However, the assay failed to recognize increasing viremia levels when YMDD mutations were paralleled by mutations in the segment targeted by the COBAS AMPLICOR probe.

This article has been cited by other articles:

• Thibault, V., Pichoud, C., Mullen, C., Rhoads, J., Smith, J. B., Bitbol, A., Thamm, S., Zoulim, F. (2007). Characterization of a New Sensitive PCR Assay for Quantification of Viral DNA Isolated from Patients with Hepatitis B Virus Infections. J. Clin. Microbiol. 45: 3948-3953 [Abstract] [Full Text]