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Journal of Clinical Microbiology, August 2006, p. 2988-2990, Vol. 44, No. 8
0095-1137/06/$08.00+0     doi:10.1128/JCM.00640-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Comparison of Dalbavancin MIC Values Determined by Etest (AB BIODISK) and Reference Dilution Methods Using Gram-Positive Organisms

Thomas R. Fritsche,1* Robert P. Rennie,2 Beth P. Goldstein,3 and Ronald N. Jones1,4

JMI Laboratories, North Liberty, Iowa,1 University of Alberta Hospital, Edmonton, Alberta, Canada,2 Pfizer, Inc., New York, New York,3 Tufts University School of Medicine, Boston, Massachusetts4

Received 24 March 2006/ Returned for modification 10 May 2006/ Accepted 17 May 2006

While standardized microdilution testing methodologies and quality control ranges exist for the novel glycolipopeptide dalbavancin, no testing methods have been described that are immediately available for routine use in clinical laboratories. In this study, we found that the dalbavancin Etest (AB BIODISK, Solna, Sweden) procedure demonstrated a high degree of agreement (100% within ±2 log2 dilution steps) with the standardized broth microdilution method, validating the use of the Etest as an alternative test for investigational or clinical purposes following regulatory approval.

* Corresponding author. Mailing address: JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317. Phone: (319) 665-3370. Fax: (319) 655-3371. E-mail: thomas-fritsche{at}jmilabs.com.

Journal of Clinical Microbiology, August 2006, p. 2988-2990, Vol. 44, No. 8
0095-1137/06/$08.00+0     doi:10.1128/JCM.00640-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Rennie, R. P., Koeth, L., Jones, R. N., Fritsche, T. R., Knapp, C. C., Killian, S. B., Goldstein, B. P. (2007). Factors Influencing Broth Microdilution Antimicrobial Susceptibility Test Results for Dalbavancin, a New Glycopeptide Agent. J. Clin. Microbiol. 45: 3151-3154 [Abstract] [Full Text]  
  • Biedenbach, D. J., Ross, J. E., Fritsche, T. R., Sader, H. S., Jones, R. N. (2007). Activity of Dalbavancin Tested against Staphylococcus spp. and {beta}-Hemolytic Streptococcus spp. Isolated from 52 Geographically Diverse Medical Centers in the United States. J. Clin. Microbiol. 45: 998-1004 [Abstract] [Full Text]  


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