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Journal of Clinical Microbiology, August 2006, p. 3021-3024, Vol. 44, No. 8
0095-1137/06/$08.00+0     doi:10.1128/JCM.02207-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

False-Positive Results of Enzyme Immunoassays for Human Immunodeficiency Virus in Patients with Uncomplicated Malaria

Anne F. Gasasira,1 Grant Dorsey,2 Moses R. Kamya,1 Diane Havlir,2 Moses Kiggundu,1 Philip J. Rosenthal,2 and Edwin D. Charlebois2*

Department of Medicine, Makerere University Medical School, Kampala, Uganda,1 Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California2

Received 20 October 2005/ Returned for modification 26 January 2006/ Accepted 8 June 2006

Malaria may impact upon human immunodeficiency virus (HIV) test results. We evaluated two HIV enzyme immunoassays (EIAs) by testing 1,965 Ugandans with malaria. We found poor positive predictive values (53% and 76%), particularly with younger age. Combining EIAs eliminated false positives but missed 21% of true positives. Performance of HIV EIAs in malaria may be unsatisfactory.

* Corresponding author. Mailing address: Department of Medicine, University of California, San Francisco, AIDS Research Institute, 50 Beale Street, 13th Floor, San Francisco, CA 94105. Phone: (415) 597-9301. Fax: (415) 597-9213. E-mail: Edwin.Charlebois{at}ucsf.edu.

Journal of Clinical Microbiology, August 2006, p. 3021-3024, Vol. 44, No. 8
0095-1137/06/$08.00+0     doi:10.1128/JCM.02207-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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