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Journal of Clinical Microbiology, September 2006, p. 3377-3380, Vol. 44, No. 9
0095-1137/06/$08.00+0     doi:10.1128/JCM.00784-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Molecular Differentiation of Treponema pallidum Subspecies

Arturo Centurion-Lara,1,2* Barbara J. Molini,1 Charmie Godornes,1 Eileen Sun,2,{dagger} Karin Hevner,1 Wesley C. Van Voorhis,1,2 and Sheila A. Lukehart1,2

Departments of Medicine,1 Pathobiology, University of Washington, Seattle, Washington 981952

Received 12 April 2006/ Returned for modification 12 June 2006/ Accepted 26 June 2006

Treponema pallidum includes three subspecies of antigenically highly related treponemes. These organisms cause clinically distinct diseases and cannot be distinguished by any existing test. In this report, genetic signatures are identified in two tpr genes which, in combination with the previously published signature in the 5' flanking region of the tpp15 gene, can differentiate the T. pallidum subspecies, as well as a simian treponeme.

* Corresponding author. Mailing address: Harborview Medical Center, Box 359779, 325 9th Ave, Seattle, WA 98104. Phone: (206) 341-5364. Fax: (206) 341-5363. E-mail: acentur{at}u.washington.edu.

{dagger} Present address: Rosetta Inpharmatics, Seattle, Wash.

Journal of Clinical Microbiology, September 2006, p. 3377-3380, Vol. 44, No. 9
0095-1137/06/$08.00+0     doi:10.1128/JCM.00784-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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