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Journal of Clinical Microbiology, September 2006, p. 3432-3434, Vol. 44, No. 9
0095-1137/06/$08.00+0     doi:10.1128/JCM.00856-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Aspergillus Galactomannan Enzyme-Linked Immunosorbent Assay Cross-Reactivity Caused by Invasive Geotrichum capitatum

Dipartimento di Scienze Pediatriche e dell'Adolescenza, Università degli Studi, Turin,¹ Dipartimento di Biotecnologie Cellulari ed Ematologia, Università La Sapienza, Rome, Italy²

Received 24 April 2006/ Returned for modification 22 June 2006/ Accepted 6 July 2006

We report three cases of invasive Geotrichum capitatum infection in patients with acute leukemia for which an enzyme-linked immunosorbent assay (ELISA) for Aspergillus galactomannan was positive, with no evidence of aspergillosis. Supernatants obtained from suspensions of 17 G. capitatum strains gave positive reactions with the Aspergillus galactomannan ELISA. These clinical and laboratory data seem to suggest that G. capitatum produces a soluble antigen that is cross-reactive with Aspergillus galactomannan.

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