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Journal of Clinical Microbiology, September 2006, p. 3448-3451, Vol. 44, No. 9
0095-1137/06/$08.00+0     doi:10.1128/JCM.01433-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Mycobacterium tuberculosis Complex and Mycobacterial Heat Shock Proteins in Lymph Node Tissue from Patients with Pulmonary Sarcoidosis

Anna Dubaniewicz,1* Miroslawa Dubaniewicz-Wybieralska,2 Adam Sternau,3 Zofia Zwolska,4 Ewa Izycka-Swieszewska,5 Ewa Augustynowicz-Kopec,4 Jaroslaw Skokowski,6 Mahavir Singh,7 and Lech Zimnoch8

Department of Pathophysiology, Medical University of Gdansk, Gdansk, Poland,1 Department of Radiology, Medical University of Gdansk, Gdansk, Poland,2 Department of Thoracic Surgery, Medical University of Gdansk, Gdansk, Poland,3 National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland,4 Department of Pathomorphology, Medical University of Gdansk, Gdansk, Poland,5 Department of Surgical Oncology, Medical University of Gdansk, Gdansk, Poland,6 LIONEX Diagnostics and Therapeutics GmbH and GBF, Braunschweig, Germany,7 Department of Medical Pathomorphology, Medical University of Bialystok, Bialystok, Poland8

Received 11 July 2006/ Accepted 14 July 2006

We demonstrated that not whole Mycobacterium tuberculosis but its particular antigens, hsp70Mtb, hsp65Mtb, and hsp16Mtb, are present in lymph node tissues of patients with sarcoidosis (SA). hsp16Mtb occurs in the early stage of SA, whereas hsp70Mtb occurs in stage II of SA. hsp65Mtb is highly expressed in the capillary vessels in lymph node tissues in patients with SA.

* Corresponding author. Mailing address: Department of Pathophysiology, Medical University of Gdansk, Debinki 7 str., 80-211 Gdansk, Poland. Phone and fax: (48 58) 349 15 10. E-mail: aduban{at}amg.gda.pl.

Journal of Clinical Microbiology, September 2006, p. 3448-3451, Vol. 44, No. 9
0095-1137/06/$08.00+0     doi:10.1128/JCM.01433-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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