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Journal of Clinical Microbiology, September 2006, p. 3452-3456, Vol. 44, No. 9
0095-1137/06/$08.00+0     doi:10.1128/JCM.00721-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Diagnosis of Gastric Syphilis by Direct Immunofluorescence Staining and Real-Time PCR Testing

Cheng-Yen Chen,1* Kai-Hua Chi,1 Robert W. George,1 David L. Cox,1 Amitabh Srivastava,2 Mário Rui Silva,3 Fátima Carneiro,4 Gregory Y. Lauwers,2 and Ronald C. Ballard1

Division of STD Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia,1 Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts,2 Department of Pathology, University Hospital of Coimbra, Coimbra, Portugal,3 Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) & Faculty of Medicine/H.S. João, Porto, Portugal4

Received 5 April 2006/ Returned for modification 15 May 2006/ Accepted 26 June 2006

We report on a case of gastric syphilis in a patient with chronic dyspepsia. The diagnosis was established by serology and the demonstration of spirochetes in diffusely inflammed gastric mucosa by staining with a fluorescent monoclonal antibody specific for pathogenic treponemes and by the detection of specific treponemal DNA sequences by a real-time PCR.

* Corresponding author. Mailing address: Division of STD Prevention, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Mail Stop G-39, 1600 Clifton Road, Atlanta, GA 30333. Phone: (404) 639-3154. Fax: (404) 639-3976. E-mail: cyc1{at}cdc.gov.

Journal of Clinical Microbiology, September 2006, p. 3452-3456, Vol. 44, No. 9
0095-1137/06/$08.00+0     doi:10.1128/JCM.00721-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Jeong, H W, Jeon, W J, Sung, R H (2008). A case of gastric syphilis with neurosyphilis presented as epigastric pain. Int J STD AIDS 19: 793-794 [Abstract] [Full Text]  
  • Pandori, M. W., Gordones, C., Castro, L., Engelman, J., Siedner, M., Lukehart, S., Klausner, J. (2007). Detection of Azithromycin Resistance in Treponema pallidum by Real-Time PCR. Antimicrob. Agents Chemother. 51: 3425-3430 [Abstract] [Full Text]  


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