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Sporothrix brasiliensis, S. globosa, and S. mexicana, Three New Sporothrix Species of Clinical Interest

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain,¹ Department of Pathology, University of Texas Health Science Center, San Antonio, Texas,² Department of Dermatology, Kanazawa Medical University, Ishikawa, Japan³

Received 16 April 2007/ Returned for modification 5 July 2007/ Accepted 31 July 2007

Sporothrix schenckii is the species responsible for sporotrichosis, a fungal infection caused by the traumatic implantation of this dimorphic fungus. Recent molecular studies have demonstrated that this species constitutes a complex of numerous phylogenetic species. Since the delineation of such species could be of extreme importance from a clinical point of view, we have studied a total of 127 isolates, most of which were received as S. schenckii, including the available type strains of species currently considered synonyms, and also some close morphological species. We have phenotypically characterized all these isolates using different culture media, growth rates at different temperatures, and numerous nutritional tests and compared their calmodulin gene sequences. The molecular analysis revealed that Sporothrix albicans, S. inflata, and S. schenckii var. luriei are species that are clearly different from S. schenckii. The combination of these phenetic and genetic approaches allowed us to propose the new species Sporothrix brasiliensis, S. globosa, and S. mexicana. The key phenotypic features for recognizing these species are the morphology of the sessile pigmented conidia, growth at 30, 35, and 37°C, and the assimilation of sucrose, raffinose, and ribitol.

Published ahead of print on 8 August 2007.

This article has been cited by other articles:

• Marimon, R., Serena, C., Gene, J., Cano, J., Guarro, J. (2008). In Vitro Antifungal Susceptibilities of Five Species of Sporothrix. Antimicrob. Agents Chemother. 52: 732-734 [Abstract] [Full Text]