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Journal of Clinical Microbiology, October 2007, p. 3277-3280, Vol. 45, No. 10
0095-1137/07/$08.00+0     doi:10.1128/JCM.02048-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Sequential Linezolid-Resistant Staphylococcus epidermidis Isolates with G2576T Mutation{triangledown}

Tao Hong,1* Xiangyang Li,1 Jie Wang,1 Cynthia Sloan,1 and Cristina Cicogna2

Clinical Microbiology, Department of Pathology,1 Division of Infectious Diseases, Hackensack University Medical Center, Hackensack, New Jersey2

Received 4 October 2006/ Returned for modification 1 December 2006/ Accepted 20 July 2007

We report on an analysis of sequential isolates of Staphylococcus epidermidis from cultures of blood obtained from a patient with acute myeloid leukemia while the patient was receiving linezolid treatment. All 12 isolates had a linezolid MIC of 32 µg/ml. A 420-bp domain V region of the 23S rRNA gene from all isolates was amplified, and their nucleotide sequences were determined. A G2576T mutation was identified in all isolates. It was estimated that 67% of the 23S rRNA genes carried this mutation. This is the first report of the failure of linezolid treatment for Staphylococcus epidermidis bacteremia associated with a G2576T mutation in an immunocompromised patient.

* Corresponding author. Mailing address: Department of Pathology, Clinical Microbiology Laboratory, Hackensack University Medical Center, 30 Prospect Ave, Hackensack, NJ 07601. Phone: (201) 996-4854. Fax: (201) 996-2156. E-mail: thong{at}humed.com

{triangledown} Published ahead of print on 1 August 2007.

Journal of Clinical Microbiology, October 2007, p. 3277-3280, Vol. 45, No. 10
0095-1137/07/$08.00+0     doi:10.1128/JCM.02048-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Feng, J., Lupien, A., Gingras, H., Wasserscheid, J., Dewar, K., Legare, D., Ouellette, M. (2009). Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance. Genome Res 19: 1214-1223 [Abstract] [Full Text]  


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