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Journal of Clinical Microbiology, October 2007, p. 3352-3359, Vol. 45, No. 10
0095-1137/07/$08.00+0     doi:10.1128/JCM.01284-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Antimicrobial Resistance among Gram-Negative Bacilli Causing Infections in Intensive Care Unit Patients in the United States between 1993 and 2004{triangledown}

Shawn R. Lockhart,1* Murray A. Abramson,2 Susan E. Beekmann,1 Gale Gallagher,2 Stefan Riedel,1 Daniel J. Diekema,1 John P. Quinn,3 and Gary V. Doern1

University of Iowa Hospital and Clinics, Division of Clinical Microbiology, Iowa City, Iowa,1 Merck and Co., Inc., Merck Research Laboratories, Upper Gwynedd, Pennsylvania,2 Cook County Hospital, Division of Infectious Diseases, Chicago, Illinois3

Received 26 June 2007/ Returned for modification 6 August 2007/ Accepted 10 August 2007

During the 12-year period from 1993 to 2004, antimicrobial susceptibility profiles of 74,394 gram-negative bacillus isolates recovered from intensive care unit (ICU) patients in United States hospitals were determined by participating hospitals and collected in a central location. MICs for 12 different agents were determined using a standardized broth microdilution method. The 11 organisms most frequently isolated were Pseudomonas aeruginosa (22.2%), Escherichia coli (18.8%), Klebsiella pneumoniae (14.2%), Enterobacter cloacae (9.1%), Acinetobacter spp. (6.2%), Serratia marcescens (5.5%), Enterobacter aerogenes (4.4%), Stenotrophomonas maltophilia (4.3%), Proteus mirabilis (4.0%), Klebsiella oxytoca (2.7%), and Citrobacter freundii (2.0%). Specimen sources included the lower respiratory tract (52.1%), urine (17.3%), and blood (14.2%). Rates of resistance to many of the antibiotics tested remained stable during the 12-year study period. Carbapenems were the most active drugs tested against most of the bacterial species. E. coli and P. mirabilis remained susceptible to most of the drugs tested. Mean rates of resistance to 9 of the 12 drugs tested increased with Acinetobacter spp. Rates of resistance to ciprofloxacin increased over the study period for most species. Ceftazidime was the only agent to which a number of species (Acinetobacter spp., C. freundii, E. aerogenes, K. pneumoniae, P. aeruginosa, and S. marcescens) became more susceptible. The prevalence of multidrug resistance, defined as resistance to at least one extended-spectrum cephalosporin, one aminoglycoside, and ciprofloxacin, increased substantially among ICU isolates of Acinetobacter spp., P. aeruginosa, K. pneumoniae, and E. cloacae.

* Corresponding author. Mailing address: University of Iowa Hospitals and Clinics, Department of Pathology-6008 BT GH, 200 Hawkins Drive, Iowa City, IA 52242-1009. Phone: (319) 356-2104. Fax: (319) 356-4916. E-mail: shawn-lockhart{at}uiowa.edu

{triangledown} Published ahead of print on 22 August 2007.

Journal of Clinical Microbiology, October 2007, p. 3352-3359, Vol. 45, No. 10
0095-1137/07/$08.00+0     doi:10.1128/JCM.01284-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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