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Large Sequence Polymorphisms Classify Mycobacterium tuberculosis Strains with Ancestral Spoligotyping Patterns

Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital and the University of California, San Francisco, California,¹ Division of Infectious Diseases and Geographic Medicine, Stanford University Medical Center, Stanford, California,² Tuberculosis Research Center, Chennai, India,³ School of Medicine, University of California, Davis, California,⁴ Institute for Systems Biology, Seattle, Washington⁵

Received 18 April 2007/ Returned for modification 24 June 2007/ Accepted 29 July 2007

Genomic deletion analysis revealed that strains of Mycobacterium tuberculosis exhibiting spoligotyping patterns with almost all spacers present belong either to a strain lineage that includes the W-Beijing strain family or to the ancestral strain lineage of M. tuberculosis.

Published ahead of print on 15 August 2007.

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