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Journal of Clinical Microbiology, October 2007, p. 3400-3403, Vol. 45, No. 10
0095-1137/07/$08.00+0     doi:10.1128/JCM.01012-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Distinguishing Acute from Chronic and Resolved Hepatitis C Virus (HCV) Infections by Measurement of Anti-HCV Immunoglobulin G Avidity Index{triangledown}

S. Klimashevskaya,1,2 A. Obriadina,2 T. Ulanova,2 G. Bochkova,2 A. Burkov,2 A. Araujo,1 Susan L. Stramer,3 Leslie H. Tobler,4 Michael P. Busch,4 and Howard A. Fields1*

Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia,1 RPC Diagnostic Systems, Nizhniy Novgorod, Russia,2 American Red Cross Scientific Support Office, Gaithersburg, Maryland,3 Blood Systems Research Institute, San Francisco, California4

Received 15 May 2007/ Returned for modification 11 July 2007/ Accepted 13 August 2007

An assay to measure avidity index (AI) was developed to diagnose incident hepatitis C virus (HCV) infections. The assay demonstrated an AI value statistically significantly lower in primary HCV infections than in chronic infections. When the assay was applied to past resolved infections, the difference in AI values was not as significant as the difference between incident and chronic infections. Lower AI values obtained in past resolved infections may be directly related to lower levels of immunoglobulin G anti-HCV in past resolved infections than in either new infections or chronic infections.

* Corresponding author. Mailing address: Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA 30333. Phone: (404) 639-3803. Fax: (404) 639-1563. E-mail: haf1{at}cdc.gov

{triangledown} Published ahead of print on 22 August 2007.

Journal of Clinical Microbiology, October 2007, p. 3400-3403, Vol. 45, No. 10
0095-1137/07/$08.00+0     doi:10.1128/JCM.01012-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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