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Journal of Clinical Microbiology, November 2007, p. 3777-3780, Vol. 45, No. 11
0095-1137/07/$08.00+0     doi:10.1128/JCM.00827-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Comparison of Plaque- and Flow Cytometry-Based Methods for Measuring Dengue Virus Neutralization{triangledown}

Annette A. Kraus, William Messer, Laura B. Haymore, and Aravinda M. de Silva*

Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599

Received 18 April 2007/ Returned for modification 22 June 2007/ Accepted 20 August 2007

As dengue vaccines enter clinical trials, there is a need for rapid and quantitative assays to measure neutralization. We have developed flow-based neutralization assays which generated results similar to those generated by the established, plaque reduction neutralization test. The flow assays are an improvement, as they use human cells and allow for high-throughput screening.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, CB#7290, University of North Carolina School of Medicine, Chapel Hill, NC 27599. Phone: (919) 843-9964. Fax: (919) 962-8103. E-mail: desilva{at}med.unc.edu

{triangledown} Published ahead of print on 5 September 2007.

Journal of Clinical Microbiology, November 2007, p. 3777-3780, Vol. 45, No. 11
0095-1137/07/$08.00+0     doi:10.1128/JCM.00827-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
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Copyright © 2007 by the American Society for Microbiology. All rights reserved.