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Journal of Clinical Microbiology, November 2007, p. 3788-3790, Vol. 45, No. 11
0095-1137/07/$08.00+0     doi:10.1128/JCM.00825-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Multicenter Trials Need To Use the Same Assay for Hepatitis C Virus Viral Load Determination{triangledown}

Syria Laperche,1 Françoise Bouchardeau,1 Vincent Thibault,2 Bruno Pozzetto,3 Sophie Vallet,4 Arielle R. Rosenberg,5 Anne-Marie Roque-Afonso,6 Michèle Gassin,7 Françoise Stoll-Keller,8 Pascale Trimoulet,9 Elyanne Gault,10 Bruno Chanzy,11 Bernard Mercier,12 Michel Branger,13 Jean-Michel Pawlotsky,14 Cécile Henquell,15 Françoise Lunel,16 Catherine Gaudy-Graffin,17 Sophie Alain,18 Marie-Laure Chaix,19 Gilles Duverlie,20 Jacques Izopet,21 and Jean-Jacques Lefrère22,23*

Centre National de Référence pour les hépatites B et C en transfusion, Département des Agents Transmissibles par le Sang, Institut National de la Transfusion Sanguine, Paris,1 Laboratoire de Virologie, Centre Hospitalo-Universitaire Pitié-Salpêtrière, Paris,2 Laboratoire de Virologie-Bactériologie, Centre Hospitalo-Universitaire, Saint-Etienne,3 Laboratoire de Microbiologie, Centre Hospitalo-Universitaire, Brest,4 Université René Descartes, Faculté de Médecine, and AP-HP, Groupe Hospitalier Cochin, Paris,5 Laboratoire de Virologie, Centre Hospitalier Paul Brousse, Villejuif,6 Institut de Biologie, Hôtel Dieu, Nantes,7 Laboratoire de Virologie, Centre Hospitalier, Strasbourg,8 Laboratoire de Virologie, Centre Hospitalo-Universitaire, Bordeaux,9 Laboratoire de Virologie-Bactériologie associé au CNR des hépatites B et C, Centre Hospitalo-Universitaire Avicenne, Bobigny,10 Laboratoire de Virologie, Centre Hospitalier, Annecy,11 Laboratoire de Virologie, Etablissement Français du Sang Bretagne, Brest,12 Laboratoire de Virologie, Centre Hospitalo-Universitaire Bichat, Paris,13 Laboratoire de Virologie-Bactériologie, Centre Hospitalo-Universitaire Henri-Mondor, Créteil,14 Laboratoire de Virologie, Centre Hospitalo-Universitaire, Clermont-Ferrand,15 Laboratoire de Virologie-Bactériologie, Centre Hospitalo-Universitaire, Angers,16 Université François Rabelais, Inserm ERI19, Centre Hospitalier Universitaire, Tours,17 Laboratoire de Virologie-Bactériologie, Centre Hospitalo-Universitaire, Limoges,18 Laboratoire de Virologie, Centre Hospitalo-Universitaire Necker, Paris,19 Laboratoire de Virologie, Centre Hospitalo-Universitaire, Amiens,20 Laboratoire de Virologie, Centre Hospitalo-Universitaire, Toulouse,21 Laboratoire d'Hématologie, Centre Hospitalo-Universitaire, Amiens,22 Département des Agents Transmissibles par le Sang, Institut National de la Transfusion Sanguine, Paris, France,23

Received 18 April 2007/ Returned for modification 17 June 2007/ Accepted 15 September 2007

This study, involving 20 laboratories and using currently available assays for hepatitis C virus RNA quantification, demonstrated that differences in viral load values are due not to interlaboratory variations but rather to the nature of the assay itself. This underlines the importance of using the same assay in multicenter studies or when monitoring antiviral therapy.

* Corresponding author. Mailing address: Institut National de la Transfusion Sanguine, 6 rue Alexandre-Cabanel, 75015 Paris, France. Phone: 44 49 30 51. Fax: 44 49 30 59. E-mail: jeanjacqueslefrere{at}wanadoo.fr

{triangledown} Published ahead of print on 3 October 2007.

Journal of Clinical Microbiology, November 2007, p. 3788-3790, Vol. 45, No. 11
0095-1137/07/$08.00+0     doi:10.1128/JCM.00825-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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