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Journal of Clinical Microbiology, November 2007, p. 3791-3794, Vol. 45, No. 11
0095-1137/07/$08.00+0     doi:10.1128/JCM.01247-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Assessment of Population Structure and Major Circulating Phylogeographical Clades of Mycobacterium tuberculosis Complex in Bangladesh Suggests a High Prevalence of a Specific Subclade of Ancient M. tuberculosis Genotypes

Zeaur Rahim,^1* Khadiza Zaman,¹ Adri G. M. van der Zanden,² Marius J. Möllers,² Dick van Soolingen,³ Rubhana Raqib,¹ Khalequ Zaman,¹ Vikarunessa Begum,⁴ Leen Rigouts,⁵ Françoise Portaels,⁵ Nalin Rastogi,⁶ and Christophe Sola^6,

International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), GPO Box 128, Dhaka 1000, Bangladesh,¹ Medical Microbiology and Infectious Diseases, Gelre Hospitals, Albert Schweitzerlaan 34, P.O. Box 9014, 7300 DS Apeldoorn, The Netherlands,² The National Mycobacteria Reference Laboratory, National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands,³ National Tuberculosis Control Program, Directorate General of Health Services, Bangladesh,⁴ Mycobacteriology Unit, Institute of Tropical Medicine, "Prince Leopold," Nationalestraat 155, Antwerp, Belgium,⁵ Unité de la Tuberculose et des Mycobactéries, Institut Pasteur de la Guadeloupe, 97165 Pointe à Pitre Cedex, Guadeloupe⁶

Received 20 June 2007/ Returned for modification 9 August 2007/ Accepted 29 August 2007

Spoligotyping was performed to study the population structure of Mycobacterium tuberculosis complex strains (n = 224) from Bangladesh. Strains were split into principal genetic group 1 (PGG 1 [75.0%]) and PGG 2 and 3 (25%). Forty-nine strains with a new spoligotype signature and considered as south or southeast Asian-linked emerging clones were designated as "Matlab type."

Published ahead of print on 5 September 2007.

Present address: Unité de Génétique Mycobactérienne, Institut Pasteur, 25-28 rue du Dr. Roux, 75024 Paris-Cedex 15, France.