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Journal of Clinical Microbiology, November 2007, p. 3807-3810, Vol. 45, No. 11
0095-1137/07/$08.00+0     doi:10.1128/JCM.01089-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Evaluation of MChip with Historic Subtype H1N1 Influenza A Viruses, Including the 1918 "Spanish Flu" Strain

Department of Chemistry and Biochemistry, UCB 215, University of Colorado at Boulder, Boulder, Colorado 80309,¹ Influenza Division, The Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, Georgia 30333,² InDevR, Inc., 2100 Central Ave., Suite 106, Boulder, Colorado 80301³

Received 29 May 2007/ Returned for modification 10 August 2007/ Accepted 1 September 2007

The robustness of a recently developed diagnostic microarray for influenza, the MChip, was evaluated with 16 historic subtype H1N1 influenza A viruses (A/H1N1), including A/Brevig Mission/1/1918. The matrix gene segments from all 16 viruses were successfully detected on the array. An artificial neural network trained with temporally related A/H1N1 viruses identified A/Brevig Mission/1/1918 as influenza virus A/H1N1 with 94% probability.

Published ahead of print on 12 September 2007.