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Journal of Clinical Microbiology, November 2007, p. 3840-3843, Vol. 45, No. 11
0095-1137/07/$08.00+0     doi:10.1128/JCM.01041-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

CASE REPORTS

"Mycobacterium ulcerans subsp. shinshuense" Isolated from a Skin Ulcer Lesion: Identification Based on 16S rRNA Gene Sequencing{triangledown}

Kazue Nakanaga,1* Norihisa Ishii,1 Koichi Suzuki,1 Kazunari Tanigawa,1 Masamichi Goto,2 Tsutomu Okabe,3 Hideaki Imada,4 Akemi Kodama,5 Tomotada Iwamoto,6 Hiroshi Takahashi,7 and Hajime Saito8

Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama-shi, Tokyo, Japan,1 Department of Human Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan,2 Department of Dermatology, National Hospital Organization, Higashi-Hiroshima Medical Center, Higashi-Hiroshima, Japan,3 Department of Orthopedic Surgery, National Hospital Organization, Higashi-Hiroshima Medical Center, Higashi-Hiroshima, Japan,4 Department of Laboratory Medicine, National Hospital Organization, Higashi-Hiroshima Medical Center, Higashi-Hiroshima, Japan,5 Department of Microbiology, Kobe Institute of Health, Kobe, Japan,6 Stanford University Medical Center, Clinical Laboratories, Palo Alto, California,7 Hiroshima Environment and Health Association, Hiroshima, Japan8

Received 22 May 2007/ Returned for modification 12 July 2007/ Accepted 11 September 2007

We describe the fourth reported case involving "Mycobacterium ulcerans subsp. shinshuense." Compared to previous cases, the infection was more invasive with extensive ulceration from the elbow to the forearm. Definitive identification involved IS2404 detection, 16S rRNA gene sequencing, and analysis of the 16S rRNA gene 3'-terminal region and the virulence plasmid pMUM001.

* Corresponding author. Mailing address: Leprosy Research Center, National Institute of Infectious Diseases, 4-2-1 Aoba-cho, Higashimurayama-shi, Tokyo 189-0002, Japan. Phone: 81-42-391-8211. Fax: 81-42-394-9092. E-mail: nakanaga{at}nih.go.jp

{triangledown} Published ahead of print on 19 September 2007.

Journal of Clinical Microbiology, November 2007, p. 3840-3843, Vol. 45, No. 11
0095-1137/07/$08.00+0     doi:10.1128/JCM.01041-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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