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Journal of Clinical Microbiology, December 2007, p. 3992-3995, Vol. 45, No. 12
0095-1137/07/$08.00+0     doi:10.1128/JCM.01202-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Prevalence of Methicillin-Resistant Staphylococcus aureus Nasal Colonization among Taiwanese Children in 2005 and 2006{triangledown}

Yhu-Chering Huang,1,3* Kao-Pin Hwang,2,3 Po-Yen Chen,4 Chih-Jung Chen,1,3 and Tzou-Yien Lin1,3

Division of Pediatric Infectious Diseases, Chang Gung Children's Hospital and Chang Gung Memorial Hospital at Linko,1 Kaohsiung, Taiwan,2 College of Medicine, Chang Gung University, Taoyuan, Taiwan,3 Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan4

Received 15 June 2007/ Returned for modification 20 August 2007/ Accepted 4 October 2007

From July 2005 to October 2006, a total of 3,046 children, of ages between 2 months and 5 years, presented for a well-child health care visit to one of three medical centers, which are located in the northern, central, and southern parts of Taiwan, and were surveyed for nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA). The overall prevalences of S. aureus and MRSA nasal carriage among the children were 23% and 7.3%, respectively (18% and 4.8% in the central region, 25% and 6.7% in the southern region, and 27% and 9.5% in the northern region). Of the 212 MRSA isolates (96%) available for analysis, a total of 10 pulsed-field gel electrophoresis (PFGE) patterns with two major patterns (C [61%] and D [28%]) were identified. One hundred forty-nine isolates (70%) contained type IV staphylococcal cassette chromosome mec (SCCmec) DNA, and 55 isolates (26%) contained SCCmec VT. The presence of Panton-Valentine Leukocidin (PVL) genes was detected in 60 isolates (28%). Most MRSA isolates belonged to one of two major clones, characterized as sequence type 59 (ST59)/PFGE C/SCCmec IV/absence of PVL genes (59%) and ST59/PFGE D/SCCmec VT/presence of PVL genes (25%). We concluded that between 2005 and 2006, 7.3% of healthy Taiwanese children were colonized by MRSA in nares. MRSA harbored in healthy children indicates an accelerated spread in the community.

* Corresponding author. Mailing address: Chang Gung Children's Hospital, Department of Pediatrics, 5, Fu-Shin Street, Kweishan, Taoyuan, Taiwan. Phone: 886-3-3281200, ext. 8202. Fax: 886-3-3288957. E-mail: ychuang{at}adm.cgmh.org.tw

{triangledown} Published ahead of print on 17 October 2007.

Journal of Clinical Microbiology, December 2007, p. 3992-3995, Vol. 45, No. 12
0095-1137/07/$08.00+0     doi:10.1128/JCM.01202-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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