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Journal of Clinical Microbiology, December 2007, p. 4036-4038, Vol. 45, No. 12
0095-1137/07/$08.00+0     doi:10.1128/JCM.01217-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Molecular Characteristics of the Mycobacterium tuberculosis LAM-RUS Family Prevalent in Central Russia{triangledown} ,{dagger}

Svetlana Dubiley,1* Eugene Kirillov,1 Anna Ignatova,1 Valentina Stepanshina,2 and Igor Shemyakin2

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya, Moscow 117997, Russia,1 State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow Region, Russia2

Received 17 June 2007/ Returned for modification 30 July 2007/ Accepted 4 October 2007

We analyzed IS6110-associated polymorphisms in the phospholipase C genes of 107 isolates of Mycobacterium tuberculosis selected to be representative of isolates circulating in central Russia. We found that the majority of Latin American-Mediterranean family strains contained an insertion in a unique position in the plcA gene, suggesting a common ancestor. This insertion can serve as a specific genetic marker for this group, which we designate the LAM-RUS family.

* Corresponding author. Mailing address: IBCH RAS, 16/10 Miklukho-Maklaya, Moscow 117997, Russia. Phone: 7(495)429-8269. Fax: 7(495)335-7103. E-mail: lana{at}ibch.ru

{triangledown} Published ahead of print on 17 October 2007.

{dagger} Supplemental material for this article may be found at http://jcm.asm.org/.

Journal of Clinical Microbiology, December 2007, p. 4036-4038, Vol. 45, No. 12
0095-1137/07/$08.00+0     doi:10.1128/JCM.01217-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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