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Molecular Characteristics of the Mycobacterium tuberculosis LAM-RUS Family Prevalent in Central Russia ^,

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya, Moscow 117997, Russia,¹ State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow Region, Russia²

Received 17 June 2007/ Returned for modification 30 July 2007/ Accepted 4 October 2007

We analyzed IS6110-associated polymorphisms in the phospholipase C genes of 107 isolates of Mycobacterium tuberculosis selected to be representative of isolates circulating in central Russia. We found that the majority of Latin American-Mediterranean family strains contained an insertion in a unique position in the plcA gene, suggesting a common ancestor. This insertion can serve as a specific genetic marker for this group, which we designate the LAM-RUS family.

Published ahead of print on 17 October 2007.

Supplemental material for this article may be found at http://jcm.asm.org/.