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Isolation and Characterization of a Novel Helicobacter Species, "Helicobacter macacae," from Rhesus Monkeys with and without Chronic Idiopathic Colitis

Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts,¹ Department of Molecular Genetics, The Forsyth Institute, Boston, Massachusetts,² Merck Research Laboratories, Merck & Co., Inc., West Point, Pennsylvania³

Received 31 May 2007/ Returned for modification 29 July 2007/ Accepted 30 September 2007

Chronic idiopathic colitis is a common clinical entity in young captive rhesus monkeys. Eight isolates, cultured from five monkeys in colony 1 with endemic diarrhea and three from colony 2 without diarrhea, were grown under microaerobic conditions on selective agar and were classified by full 16S rRNA sequence, biochemical, and phenotypic analysis as a novel helicobacter, "Helicobacter macacae" (proposed name). All eight strains of H. macacae had 99.5% identical 16S rRNA sequences.

Published ahead of print on 10 October 2007.