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Journal of Clinical Microbiology, December 2007, p. 4085-4087, Vol. 45, No. 12
0095-1137/07/$08.00+0     doi:10.1128/JCM.01714-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Mycobacterium bovis BCG Vertebral Osteomyelitis after Intravesical BCG Therapy, Diagnosed by PCR-Based Genomic Deletion Analysis{triangledown}

Takuya Nikaido,1 Kei Ishibashi,2 Koji Otani,1 Shoji Yabuki,1 Shinichi Konno,1 Shuichi Mori,2 Kazutaka Ohashi,2 Takashi Ishida,4 Michiko Nakano,3 Osamu Yamaguchi,3 Tatsuo Suzutani,2* and Shinichi Kikuchi1

Department of Orthopedics,1 Department of Microbiology,2 Department of Urology,3 Department of Pulmonary Medicine, Fukushima Medical University, Fukushima 960-1295, Japan4

Received 29 August 2007/ Returned for modification 6 October 2007/ Accepted 10 October 2007

We report a case of Mycobacterium bovis BCG vertebral osteomyelitis 1.8 years after intravesical BCG therapy for bladder cancer. We differentiated BCG from other Mycobacterium tuberculosis complex members by PCR analysis of deletion regions and started an appropriate chemotherapy regimen resulting in the remission of symptoms within 1 month.

* Corresponding author. Mailing address: Department of Microbiology, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan. Phone: 81-24-547-1157. Fax: 81-24-548-5072. E-mail: suzutani{at}fmu.ac.jp

{triangledown} Published ahead of print on 24 October 2007.

Journal of Clinical Microbiology, December 2007, p. 4085-4087, Vol. 45, No. 12
0095-1137/07/$08.00+0     doi:10.1128/JCM.01714-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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Copyright © 2007 by the American Society for Microbiology. All rights reserved.