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Journal of Clinical Microbiology, February 2007, p. 604-606, Vol. 45, No. 2
0095-1137/07/$08.00+0     doi:10.1128/JCM.01325-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Comparison of Cepheid's Analyte-Specific Reagents with BD Directigen for Detection of Respiratory Syncytial Virus{triangledown}

Jennifer S. Goodrich1 and Melissa B. Miller1,2*

University of North Carolina Hospitals, Clinical Microbiology-Immunology Laboratory,1 University of North Carolina School of Medicine, Department of Pathology and Laboratory Medicine, Chapel Hill, North Carolina2

Received 27 June 2006/ Returned for modification 10 October 2006/ Accepted 7 December 2006

For detection of respiratory syncytial virus (RSV), the BD Directigen RSV rapid antigen assay was compared to Cepheid's real-time reverse transcriptase PCR RSV analyte-specific reagents. The Directigen RSV assay resulted in a 23% false-negative rate, using PCR and chart review as the gold standard, indicating that rapid RSV PCR results would be advantageous.

* Corresponding author. Mailing address: Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Campus Box 7525, Chapel Hill, NC 27599. Phone: (919) 966-3723. Fax: (919) 966-0486. E-mail: mbmiller{at}unch.unc.edu.

{triangledown} Published ahead of print on 20 December 2006.

Journal of Clinical Microbiology, February 2007, p. 604-606, Vol. 45, No. 2
0095-1137/07/$08.00+0     doi:10.1128/JCM.01325-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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