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Journal of Clinical Microbiology, February 2007, p. 627-630, Vol. 45, No. 2
0095-1137/07/$08.00+0     doi:10.1128/JCM.00816-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The Sensitivity of the OptiMAL Rapid Diagnostic Test to the Presence of Plasmodium falciparum Gametocytes Compromises Its Ability To Monitor Treatment Outcomes in an Area of Papua New Guinea in which Malaria Is Endemic{triangledown}

Ivo Mueller,1* Inoni Betuela,1 Meza Ginny,1 John C. Reeder,1 and Blaise Genton2

PNG Institute of Medical Research, P.O. Box 378, Madang 511, Papua New Guinea,1 Swiss Tropical Institute, Socinstrasse, Postfach, 4002 Basel, Switzerland2

Received 17 April 2006/ Returned for modification 27 May 2006/ Accepted 21 November 2006

Using in vivo samples from treatment failure malaria cases, we demonstrate the high sensitivity of the parasite lactase dehydrogenase (pLDH)-based OptiMAL rapid diagnostic test in the detection of P. falciparum gametocytes. This high sensitivity limits the use of pLDH-based tests in the monitoring of treatment outcomes in circumstances where gametocytemia is common.

* Corresponding author. Mailing address: PNG Institute of Medical Research, P.O. Box 378, Madang 511, Papua New Guinea. Phone: 011 675 732 2800. Fax: 011 675 732 1998. E-mail: pngimr_ivo{at}datec.net.pg.

{triangledown} Published ahead of print on 29 November 2006.

Journal of Clinical Microbiology, February 2007, p. 627-630, Vol. 45, No. 2
0095-1137/07/$08.00+0     doi:10.1128/JCM.00816-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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Copyright © 2007 by the American Society for Microbiology. All rights reserved.