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Journal of Clinical Microbiology, February 2007, p. 659-661, Vol. 45, No. 2
0095-1137/07/$08.00+0     doi:10.1128/JCM.02209-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Detection of Treponema pallidum subsp. pallidum from Skin Lesions, Serum, and Cerebrospinal Fluid in an Infant with Congenital Syphilis after Clindamycin Treatment of the Mother during Pregnancy{triangledown}

Vladana Woznicová,1* David Smajs,2 Dan Wechsler,3 Petra Matejková,2 and Magdalena Flasarová2

Department of Medical Microbiology, Faculty of Medicine, Masaryk University, Pekarská 53, 65691 Brno, Czech Republic,1 Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A6, 625 00 Brno, Czech Republic,2 University Hospital Brno, Children's Medical Center, second Department of Pediatrics, NICU, Cernopolní 9, 625 00 Brno, Czech Republic3

Received 28 October 2006/ Returned for modification 15 November 2006/ Accepted 27 November 2006

We report here a case of congenital syphilis in a newborn after clindamycin treatment in pregnancy. Using PCR detection of tmpC (TP0319) and DNA sequencing of the genes TP0136 and TP0548, DNA sequences identical to Treponema pallidum subsp. pallidum strain SS14 were detected in the infant's skin lesions, serum, and cerebrospinal fluid.

* Corresponding author. Mailing address: Department of Medical Microbiology, Faculty of Medicine, Masaryk University, Pekarska 53, 656 91 Brno, Czech Republic. Phone: 420 543 183 097. Fax: 420 543 183 089. E-mail: vladana.woznicova{at}fnusa.cz.

{triangledown} Published ahead of print on 6 December 2006.

Journal of Clinical Microbiology, February 2007, p. 659-661, Vol. 45, No. 2
0095-1137/07/$08.00+0     doi:10.1128/JCM.02209-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Matejkova, P., Flasarova, M., Zakoucka, H., Borek, M., Kremenova, S., Arenberger, P., Woznicova, V., Weinstock, G. M., Smajs, D. (2009). Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum. J Med Microbiol 58: 832-836 [Abstract] [Full Text]  
  • Salazar, J. C., Rathi, A., Michael, N. L., Radolf, J. D., Jagodzinski, L. L. (2007). Assessment of the Kinetics of Treponema pallidum Dissemination into Blood and Tissues in Experimental Syphilis by Real-Time Quantitative PCR. Infect. Immun. 75: 2954-2958 [Abstract] [Full Text]  


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