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Journal of Clinical Microbiology, February 2007, p. 668-671, Vol. 45, No. 2
0095-1137/07/$08.00+0     doi:10.1128/JCM.01657-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Necrotizing Fasciitis Due to a Methicillin-Sensitive Staphylococcus aureus Isolate Harboring an Enterotoxin Gene Cluster{triangledown}

William R. Morgan,1 Michael D. Caldwell,2 Jennifer M. Brady,3 Mary E. Stemper,4 Kurt D. Reed,3,5 and Sanjay K. Shukla3*

Department of Internal Medicine,1 Department of Surgery,2 Department of Pathology, Marshfield Clinic, Marshfield, Wisconsin,5 Molecular Microbiology Laboratory, Marshfield Clinic Research Foundation, Marshfield, Wisconsin,3 Marshfield Laboratories, Marshfield, Wisconsin4

Received 10 August 2006/ Returned for modification 12 August 2006/ Accepted 21 November 2006

Benign papular eruption on the left leg of a 72-year-old diabetic man developed into rapidly spreading necrotizing fasciitis despite antimicrobial therapy and surgical debridements. This led to eventual amputation to control the infection. The etiological agent was a Staphylococcus aureus isolate harboring the enterotoxin gene cluster seg, sei, sem, sen, and seo but lacked all common toxin genes, including Panton-Valentine leukocidin.

* Corresponding author. Mailing address: Molecular Microbiology Laboratory, Marshfield Clinic Research Foundation, 1000 North Oak Avenue, Marshfield, WI 54449. Phone: (715) 389-5363. Fax: (715) 389-3808. E-mail: shukla.sanjay{at}mcrf.mfldclin.edu.

{triangledown} Published ahead of print on 13 December 2006.

Journal of Clinical Microbiology, February 2007, p. 668-671, Vol. 45, No. 2
0095-1137/07/$08.00+0     doi:10.1128/JCM.01657-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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