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Journal of Clinical Microbiology, March 2007, p. 1016-1018, Vol. 45, No. 3
0095-1137/07/$08.00+0     doi:10.1128/JCM.02085-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Cultivation-Independent Analysis of Changes in Bacterial Vaginosis Flora Following Metronidazole Treatment{triangledown}

Michael J. Ferris,1,2* Johana Norori,2 Marcela Zozaya-Hinchliffe,2 and David H. Martin3

Department of Pediatrics,1 Department of Internal Medicine, Louisiana State University Health Sciences Center, New, Orleans, Louisiana 70112,3 The Research Institute for Children, New Orleans, Louisiana 701182

Received 10 October 2006/ Returned for modification 20 November 2006/ Accepted 19 December 2006

PCR was used to survey bacterial vaginosis flora before and after metronidazole treatment. The species composition for pretreatment patients was variable. Lactobacillus iners was prominent in all patients posttreatment. Atopobium vaginae concentrations were highest for patients who failed or responded incompletely to treatment and lowest for patients who were cured.

* Corresponding author. Mailing address: Children's Hospital, R&E Bldg., 200 Henry Clay Ave., New Orleans, LA 70118. Phone: (504) 896-2736. Fax: (504) 894-5379. E-mail: mferris{at}chnola-research.org.

{triangledown} Published ahead of print on 3 January 2007.

Journal of Clinical Microbiology, March 2007, p. 1016-1018, Vol. 45, No. 3
0095-1137/07/$08.00+0     doi:10.1128/JCM.02085-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Fredricks, D. N., Fiedler, T. L., Thomas, K. K., Mitchell, C. M., Marrazzo, J. M. (2009). Changes in Vaginal Bacterial Concentrations with Intravaginal Metronidazole Therapy for Bacterial Vaginosis as Assessed by Quantitative PCR. J. Clin. Microbiol. 47: 721-726 [Abstract] [Full Text]  
  • Zozaya-Hinchliffe, M., Martin, D. H., Ferris, M. J. (2008). Prevalence and Abundance of Uncultivated Megasphaera-Like Bacteria in the Human Vaginal Environment. Appl. Environ. Microbiol. 74: 1656-1659 [Abstract] [Full Text]  
  • Jakobsson, T., Forsum, U. (2007). Lactobacillus iners: a Marker of Changes in the Vaginal Flora?. J. Clin. Microbiol. 45: 3145-3145 [Full Text]  


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