This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eda, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eda, H.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, March 2007, p. 771-782, Vol. 45, No. 3
0095-1137/07/$08.00+0     doi:10.1128/JCM.01236-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Contrasting Geographic Distribution Profiles of the Herpes Simplex Virus Type 1 BgOL and BgKL Variants in Japan Suggest Dispersion and Replacement{triangledown}

Hiroyuki Eda,1,2,3,§ Shigeru Ozawa,4 Kamesaburo Yoshino,4,{ddagger} Kazuo Yanagi,1,2* and the Cooperation Group for HSV-1 RFLP Variant Study{dagger}

Herpesvirus Laboratory, Department of Virus I, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan,1 Institute of Basic Medical Sciences, Tsukuba University, Tennodai 1-1-1, Tsukuba City, Ibaraki 305-8572, Japan,2 The Program of Environmental Sciences, Tsukuba University, Tsukuba, Ibaraki 305-8572, Japan,3 Yamanashi Institute of Health, Fujimi 1-7-31, Kofu City, Yamanashi Prefecture 400-0027, Japan4

Received 16 June 2006/ Returned for modification 20 August 2006/ Accepted 27 December 2006

Thelifelong latent infection-reactivation mode of infection of herpes simplex virus type 1 (HSV-1) transmitted by close contact has allowed a diversity of restriction fragment length polymorphism (RFLP) variations to accumulate in human populations. Whether and how the variants of the HSV-1 that is ubiquitous worldwide spread to different human populations is not clear. In our previous study the geographically gradient distribution of the HSV-1 BgKL variant, which is a good marker for the BgKL:SaCFJM:SaGHM:SaD/EL:KpMS variant, suggested that BgKL dispersed geographically. Southern hybridization analyses showed that in BgKL the BglII cleavage site between the BglII K and small "Q/#13" fragments is lost, the SalI cleavage sites between the SalI J and C and between SalI F and J fragments are lost, and the SalI E fragment is abnormally large (SaEL variation). The RFLP and geographic distribution of one more HSV-1 RFLP variant, BgOL, were comparatively analyzed. The BglII cleavage site between the BglII O and Q/#13 fragments is lost in BgOL. BgOL clinical isolates were not associated with any of the SaCFJM, SaEL, SaGHM, or KpMS variations, whereas one-fourth of the non-BgOL:non-BgKL isolates was associated with SaCFJM and SaGHM, indicating that BgKL and BgOL are distant in terms of diversification. BgOL is distributed highly in the northeastern region and the southwestern island of Kyushu but is rare between the two regions in Japan, in a remarkable contrast to BgKL. These are the first epidemiologic data to show contrasting geographic distribution profiles of two HSV-1 variants and suggest the gradual dispersion and replacement of HSV-1 variants.

* Corresponding author. Present address: AIDS Research Center, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku, Tokyo 162-8640, Japan. Phone: (81) 3-5285-1111. Fax: (81) 3-5285-1150. E-mail: kyanagi{at}nih.go.jp.

{triangledown} Published ahead of print on 10 January 2007.

§ Present address: Discovery Biology Research, Nagoya Laboratories, Pfizer Japan, Taketoyo 5-2, Aichi 470-2393, Japan.

{ddagger} Deceased after the completion of this study.

{dagger} Contributing members of the Cooperation Group are listed in the Acknowledgments.

Journal of Clinical Microbiology, March 2007, p. 771-782, Vol. 45, No. 3
0095-1137/07/$08.00+0     doi:10.1128/JCM.01236-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ban, F., Asano, S., Ozawa, S., Eda, H., Norman, J., Stroop, W. G., Yanagi, K. (2008). Analysis of herpes simplex virus type 1 restriction fragment length polymorphism variants associated with herpes gladiatorum and Kaposi's varicelliform eruption in sumo wrestlers. J. Gen. Virol. 89: 2410-2415 [Abstract] [Full Text]  
  • Ozawa, S., Eda, H., Ishii, Y., Ban, F., Funabashi, T., Hata, S., Hayashi, K., Iga, H., Ikushima, T., Ishiko, H., Itagaki, T., Kawana, R., Kobayashi, S., Ogino, T., Sekizawa, T., Shimomura, Y., Shiota, H., Mori, R., Nakakita, T., Numazaki, Y., Ozaki, Y., Yamamoto, S., Yoshino, K., Yanagi, K. (2007). The Herpes Simplex Virus Type 1 BgKL Variant, Unlike the BgOL Variant, Shows a Higher Association with Orolabial Infection than with Infections at Other Sites, Supporting the Variant-Dispersion-Replacement Hypothesis. J. Clin. Microbiol. 45: 2183-2190 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»