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Journal of Clinical Microbiology, April 2007, p. 1185-1189, Vol. 45, No. 4
0095-1137/07/$08.00+0     doi:10.1128/JCM.02076-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Distribution Study of Chlamydia trachomatis Serovars among High-Risk Women in China Performed Using PCR-Restriction Fragment Length Polymorphism Genotyping{triangledown}

Xing Gao,1 Xiang-Sheng Chen,1* Yue-Ping Yin,1 Ming-Ying Zhong,1 Mei-Qin Shi,1 Wan-Hui Wei,1 Qiang Chen,1 Rosanna W. Peeling,2 and David Mabey3

National Center for STD Control, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC) Institute of Dermatology, 12 Jiangwangmiao Street, Nanjing 20042, China,1 UNICEF/UNDP/World Bank/WHO Special Programme for Research & Training in Tropical Diseases (TDR), World Health Organization, 20 Avenue Appia, CH-1211 Geneva 27, Switzerland,2 London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom3

Received 9 October 2006/ Returned for modification 1 January 2007/ Accepted 4 February 2007

This was one of the first epidemiological studies in China focused on genital Chlamydia trachomatis serotype distribution in high-risk female populations using omp1 gene-based restriction fragment length polymorphism analysis. One thousand seven hundred seventy cervical swab samples from women attending sexually transmitted disease clinics and female sex workers in six cities in China (Shenzhen and Guangzhou in southern China, Nanjing and Shanghai in eastern China, and Nanning and Chengdu in southwestern China) were subjected to serovar genotyping. The proportion of omp1 genes successfully amplified in 240 C. trachomatis plasmid-positive samples was 94.2% (226/240). Serotypes E (n = 63; 27.9%), F (n = 53; 23.5%), G (n = 28; 12.4%), and D (n = 25; 11.1%) were most prevalent. Though there was no significant difference in the geographic distribution of C. trachomatis, serotype E was predominant in the South (32.1%) and East (27.1%), while serotype F was predominant in the Southwest (28.3%). Serotype F infection was associated with young age and single status. Serovar G was associated with lower abdominal pain; 47.5% of asymptomatic patients were infected with serovar E. These results provide information on distribution of genital C. trachomatis serotypes among high-risk women in China and indicate that high-risk women, including those who are asymptomatic, can be infected with multiple serovars of C. trachomatis, revealing exposure to multiple sources of infection. Although the scope for generalizations is limited by our small sample size, our results showing clinical correlations with genotypes are informative.

* Corresponding author. Mailing address: Department of STD Epidemiology, National Center for STD Control, 12 Jiangwangmiao Street, Nanjing 210042, China. Phone: 86-25-8547-8901. Fax: 86-25-8547-8958. E-mail: chenxs{at}vip.163.com

{triangledown} Published ahead of print on 14 February 2007.

Journal of Clinical Microbiology, April 2007, p. 1185-1189, Vol. 45, No. 4
0095-1137/07/$08.00+0     doi:10.1128/JCM.02076-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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  • Petrovay, F., Balla, E., Nemeth, I., Gonczol, E. (2009). Genotyping of Chlamydia trachomatis from the endocervical specimens of high-risk women in Hungary. J Med Microbiol 58: 760-764 [Abstract] [Full Text]  
  • Quint, K., Porras, C., Safaeian, M., Gonzalez, P., Hildesheim, A., Quint, W., van Doorn, L.-J., Silva, S., Melchers, W., Schiffman, M., Rodriguez, A. C., Wacholder, S., Freer, E., Cortes, B., Herrero, R., for the Costa Rican Vaccine Trial Group, (2007). Evaluation of a Novel PCR-Based Assay for Detection and Identification of Chlamydia trachomatis Serovars in Cervical Specimens. J. Clin. Microbiol. 45: 3986-3991 [Abstract] [Full Text]  


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