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Journal of Clinical Microbiology, April 2007, p. 1319-1321, Vol. 45, No. 4
0095-1137/07/$08.00+0     doi:10.1128/JCM.01818-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Significant Genetic and Antigenic Variability within the env Gene of Systemic Human Immunodeficiency Virus Type 1 Group O Populations during the Natural Course of a Heterosexual Infection: a Pilot Study{triangledown}

Laurent Andréoletti,1* Brigitte Réveil,2 Hélène Moret,1 Véronique Brodard,1 Frédérique Philbert,2 Thierry Tabary,2 and Jacques Henri Max Cohen2

Laboratoire de Virologie Hôpital Robert Debré, IFR 53/EA-3798, CHU et Faculté de Médecine de Reims, Reims, France,1 Laboratoire d'Immunologie Hôpital Robert Debré, IFR 53/EA-3798, CHU et Faculté de Médecine de Reims, Reims, France2

Received 1 September 2006/ Returned for modification 26 November 2006/ Accepted 13 January 2007

We assessed the genetic and the antigenic variability within the env gene of peripheral blood human immunodeficiency virus (HIV) type 1 (HIV-1) group O populations during the natural course of a female heterosexual infection. Our data revealed the existence of a significant increase in amino acid sequence variability within the C2-V3 and gp41 regions (P = 0.023 and P < 0.001, respectively) in association with substitutions within neutralizing epitope sequences usually selected for HIV serological assays. These antigenic variations might significantly decrease the sensitivity of classical HIV enzyme-linked immunosorbent assays with blood samples of subjects heterosexually infected by HIV-1 group O strains. These findings may be of significant use both to devise diagnostic tools and to pursue suitable therapeutic modalities in cases of heterosexual infection by outlier HIV-1 strains.

* Corresponding author. Mailing address: Laboratoire de Virologie et EA-3798, Hôpital Robert Debré, Avenue du Général Koenig, 51092 Reims Cedex, France. Phone: (33) 3 26 78 39 93. Fax: (33) 3 26 78 41 34. E-mail: landreoletti{at}chu-reims.fr

{triangledown} Published ahead of print on 31 January 2007.

Journal of Clinical Microbiology, April 2007, p. 1319-1321, Vol. 45, No. 4
0095-1137/07/$08.00+0     doi:10.1128/JCM.01818-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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